Evidence map›Paper›PMID 31921136›Full record

ReviewFrontiers in immunology2019

Immunomodulation as a Novel Strategy for Prevention and Treatment of

Monica C Gestal, Hannah M Johnson, Eric T Harvill

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Generating enhanced mucosal immunity againstFrontiers in immunology · 2023
    Article
  3. Review
  4. Article
  5. Conquering the host:Frontiers in microbiology · 2022
    Review
  6. Review
  7. Article
  8. Review
  9. DisruptingMicroorganisms · 2020
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Monica C GestalDepartment of Infectious Diseases, College of Veterinary Sciences, University of Georgia, Athens, GA, United States.
Hannah M JohnsonDepartment of Infectious Diseases, College of Veterinary Sciences, University of Georgia, Athens, GA, United States.
Eric T HarvillDepartment of Infectious Diseases, College of Veterinary Sciences, University of Georgia, Athens, GA, United States.
University of Georgia · US

Funding

Evolution of the Bordetellae from Commensals to PathogensR01GM083113 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T · 2008 to 2011
$2.1M
Comparative Immunobiology of the bordetellaeR01AI053075 · NIAID · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI HARVILL, ERIC T. · 2003 to 2007
$1.4M
The Microbiota Pathogen CompetitionR01GM113681 · NIGMS · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2015 to 2018
$1.3M
An optimized mouse model of Bordetella pertussis infectionR21AI142678 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2019 to 2020
$414k
A Novel Polysaccharide Structure that Mediates TransmissionR21AI140399 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2018 to 2019
$413k
In vivo vaccine-driven evolution in Bordetella pertussisR21AI116186 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2015 to 2016
$411k
Bordetella sp. Versus MicrobiotaR56AI107016 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T · 2014 to 2014
$377k
EMERGENCE OF HUMAN PATHOGENS IN THE GENUS BORDETELLAR56AI065507 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T. · 2007 to 2007
$363k
NIAID NIH HHS R01 AI053075NIAID NIH HHS R21 AI116186NIAID NIH HHS R21 AI140399NIAID NIH HHS R21 AI142678NIAID NIH HHS R56 AI065507NIAID NIH HHS R56 AI107016NIGMS NIH HHS R01 GM083113NIGMS NIH HHS R01 GM113681
6 · The paper itself

Abstract

Well-adapted pathogens have evolved to survive the many challenges of a robust immune response. Defending against all host antimicrobials simultaneously would be exceedingly difficult, if not impossible, so many co-evolved organisms utilize immunomodulatory tools to subvert, distract, and/or evade the host immune response.

Indexed as

BordetellaBordetella InfectionsHumansadjuvantsBordetellaimmunomodulationpertussisToll-receptors

Identifiers

PMID31921136
PMCPMC6923730
OpenAlexW2999874298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.