Evidence map›Paper›PMID 31920992›Full record

ArticleFrontiers in endocrinology2019

Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes.

Saumik Biswas, Shali Chen, Guang Liang, Biao Feng, Lu Cai, Zia A Khan, Subrata Chakrabarti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Saumik BiswasDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Shali ChenDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Guang LiangChemical Biology Research Centre, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.
Biao FengDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Lu CaiDepartment of Pediatrics, Pediatric Research Institute, University of Louisville, Louisville, KY, United States.
Zia A KhanDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Subrata ChakrabartiDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Western University · CAUniversity of Louisville · USWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation and oxidative stress lead to a multitude of adverse cellular responses in target organs of chronic diabetic complications. Curcumin, a highly investigated phytochemical, has been shown to exhibit both anti-inflammatory and antioxidant activities. However, the clinical application of curcumin has been greatly limited due to a poor pharmacokinetic profile. To overcome these limitations, we have generated analogs of curcumin to enhance bioavailability and offer a preferable pharmacokinetic profile. Here, we explored the effects of two mono-carbonyl curcumin analogs, L2H21 and L50H46, in alleviating indices of inflammation and oxidative stress in cell culture and mouse model of diabetic complications. Our results show that L2H21 and L50H46 normalize inflammatory mediators (

Indexed as

angiogenesiscurcumin analogsdiabetic complicationsfibrosisinflammation

Identifiers

PMID31920992
PMCPMC6930691
OpenAlexW2995357389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.