ReviewFrontiers in endocrinology2019
Molecular and Environmental Mechanisms Regulating Puberty Initiation: An Integrated Approach.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Comparison of central precocious puberty frequency before and during COVID-19: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Association Study BetweenInternational journal of molecular sciences · 2026Article
- Ambient Air Pollution, Polycyclic Aromatic Hydrocarbons, and Pubertal Development: A Critical Review of Emerging Evidence.Current environmental health reports · 2026Review
- Effectiveness and Safety of Hormonal Treatments in Children with Growth Disorders: A Systematic Review of Clinical Evidence.Clinics and practice · 2026Review
- Induction of puberty in hypogonadal forms of primary amenorrhoea: current evidence and future perspectives.Endocrine connections · 2026Review
- Research on the influence of bisphenol A on precocious puberty based on network toxicology and molecular dynamics simulation.Frontiers in endocrinology · 2026Article
- Comprehensive profiling of phenotypic features of memory T- and B-cells from birth to the onset of old age.Frontiers in aging · 2026Article
- Does consumption of a high-fructose diet during pregnancy and lactation exacerbate the effects of maternal exposure to cadmium on development and metabolic function of mouse offspring?Journal of toxicology and environmental health. Part A · 2026Article
- Early life growth is related to pubertal growth and adult height - a QEPS-model analysis.Pediatric research · 2025Article
- Impact of the COVID-19 pandemic on the incidence of central precocious puberty: A PRISMA-ScR-COMPLIANT scoping review.Archives of endocrinology and metabolism · 2025Article
- Metabolomics and transcriptomics analyses reveal the complex molecular mechanisms by which the hypothalamus regulates sexual development in female goats.BMC genomics · 2025Article
- A Leptin Receptor Mutation Which Impairs Fertility in Ewes Causes Delayed Puberty in Male and Female Mice.Endocrinology · 2025Article
- Associations between birth characteristics, pubertal timing and adult height.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Outcomes of Patients With Familial Central Precocious Puberty due to Mutations ofInternational journal of endocrinology · 2025Article
- Precocious puberty, pandemic and beyond.Pituitary · 2024Review
- Article
- Protecting our future: environmental hazards and children's health in the face of environmental threats: a comprehensive overview.Clinical and experimental pediatrics · 2024Article
- The Impact of Socioeconomic Status on Visual Acuity Changes in Schoolchildren: A One-Year Follow-Up.Children (Basel, Switzerland) · 2024Article
- Indications of younger age at menarche in Greek adolescents but with no relation to body mass index.Hormones (Athens, Greece) · 2024Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying the initiation of puberty, one of the cornerstones of human evolution, have not been fully elucidated as yet. However, recently, an accumulating body of evidence has helped unravel several critical aspects of the process. It is clear that a change in the pattern of pituitary gonadotropin secretion serves as a hormonal trigger for puberty induction. This change is directly guided by the hypothalamic GnRH pulse generation, a phenomenon regulated by the Kisspeptin-Neurokinin-Dynorphin (KNDy) system also in the hypothalamus. This represents the kisspeptin molecule, which is crucial in augmenting GnRH secretion at puberty, whose secretion is fine-tuned by the opposing signals neurokinin B and dynorphin. Recently, the novel kisspeptin inhibitory signal MKRN3 was described, whose role in puberty initiation provided further insight into the mechanistic aspects of pubertal onset. Furthermore, the description of higher inhibitory and stimulatory signals acting upstream of the KNDy neurons suggested that the trigger point of puberty is located upstream of the KNDy system and the GnRH pulse generator. However, the mechanism of pubertal onset should not be considered as an isolated closed loop system. On the contrary, it is influenced by such factors as adipose tissue, gastrointestinal function, adrenal androgen production, energy sensing, and physical and psychosocial stress. Also, fetal and early life stressful events, as well as exposure to endocrine disruptors, may play important roles in pubertal initiation, the latter primarily through epigenetic modifications. Here we present the available data in the field and attempt to provide an integrated view of this unique and crucial phenomenon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.