Evidence map›Paper›PMID 31920733›Full record

ArticleFrontiers in psychiatry2019

A Proof-of-Mechanism Study to Test Effects of the NMDA Receptor Antagonist Lanicemine on Behavioral Sensitization in Individuals With Symptoms of PTSD.

Marijn Lijffijt, Charles E Green, Nicholas Balderston, Tabish Iqbal, Megan Atkinson, Brittany Vo-Le, Bylinda Vo-Le, Brittany O'Brien, Christian Grillon, Alan C Swann and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
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  10. Article
  11. Does mismatch negativity have utility for NMDA receptor drug development in depression?Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Marijn LijffijtResearch Service Line, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
Charles E GreenDepartment of Psychiatry and Behavioral Sciences, UTHealth McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
Nicholas BalderstonSection on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Tabish IqbalResearch Service Line, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
Megan AtkinsonDepartment of Anesthesiology, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
Brittany Vo-LeResearch Service Line, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
Bylinda Vo-LeResearch Service Line, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
Brittany O'BrienResearch Service Line, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
Christian GrillonDepartment of Pediatrics - Center for Evidence Based Medicine, UTHealth McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
Alan C SwannMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States.
Sanjay J MathewMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States.
Baylor College of Medicine · USMichael E. DeBakey VA Medical Center · USThe University of Texas Health Science Center at Houston · USNational Institute of Mental Health · US

Funding

NMDA receptor modulation for hyperarousal in PTSDR61MH110540 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI MATHEW, SANJAY J · 2016 to 2018
$1.4M
NIMH NIH HHS R61 MH110540
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anxiety potentiated startlebehavioral sensitizationhyperarousalneurophysiologyNMDA receptorpost-traumatic stress disorder

Identifiers

PMID31920733
PMCPMC6923195
OpenAlexW2999304136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.