ArticleFrontiers in physiology2019
Clinical Usefulness of Computational Modeling-Guided Persistent Atrial Fibrillation Ablation: Updated Outcome of Multicenter Randomized Study.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02171364 (Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Prospective Randomized Study
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Clinical Outcomes of Computational Virtual Mapping-Guided Catheter Ablation in Patients With Persistent Atrial Fibrillation: A Multicenter Prospective Randomized Clinical Trial.Frontiers in cardiovascular medicine · 2021Trial
- Validating medical digital twins for clinical decision support: beyond predictive accuracy.JAMIA open · 2026Review
- Digital Twin Models in Atrial Fibrillation: Charting the Future of Precision Therapy?Journal of personalized medicine · 2025Review
- From bits to bedside: entering the age of digital twins in cardiac electrophysiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Clinical usefulness of digital twin guided virtual amiodarone test in patients with atrial fibrillation ablation.NPJ digital medicine · 2024Article
- Anti- and pro-fibrillatory effects of pulmonary vein isolation gaps in human atrial fibrillation digital twins.NPJ digital medicine · 2024Article
- A Review of Personalised Cardiac Computational Modelling Using Electroanatomical Mapping Data.Arrhythmia & electrophysiology review · 2024Review
- Computational Modeling and Simulation of the Fibrotic Human Atria.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A systematic review of cardiacProgress in biomedical engineering (Bristol, England) · 2023Review
- Virtual Ablation of Atrial Fibrillation in Patients With Persistent Atrial Fibrillation: An Unexplored Niche.Korean circulation journal · 2022Article
- Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation Targeting Restitution Parameter-Guided Catheter Ablation: CUVIA-REGAB Prospective Randomized Study.Korean circulation journal · 2022Article
- Anti-atrial Fibrillation Effects of Pulmonary Vein Isolation With or Without Ablation Gaps: A Computational Modeling Study.Frontiers in physiology · 2022Article
- Ablation and antiarrhythmic drug effects onFrontiers in cardiovascular medicine · 2022Article
- Current progress of computational modeling for guiding clinical atrial fibrillation ablation.Journal of Zhejiang University. Science. B · 2021Review
- Characterizing the arrhythmogenic substrate in personalized models of atrial fibrillation: sensitivity to mesh resolution and pacing protocol in AF models.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
- Computational Modeling for Antiarrhythmic Drugs for Atrial Fibrillation According to Genotype.Frontiers in physiology · 2021Article
- Translational applications of computational modelling for patients with cardiac arrhythmias.Heart (British Cardiac Society) · 2020Review
- Creation and application of virtual patient cohorts of heart models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- State of the art paper: Cardiac computed tomography of the left atrium in atrial fibrillation.Journal of cardiovascular computed tomographyReview
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCatheter ablation of persistent atrial fibrillation (AF) is still challenging, no optimal extra-pulmonary vein lesion set is known. We previously reported the clinical feasibility of computational modeling-guided AF catheter ablation.
methodsWe randomly assigned 118 patients with persistent AF (77.8% men, age 60.8 ± 9.9 years) to the computational modeling-guided ablation group (53 patients) and the empirical ablation group (55 patients) based on the operators' experience. For virtual ablation, four virtual linear and one electrogram-guided lesion sets were tested on patient heart computed tomogram-based models, and the lesion set with the fastest termination time was reported to the operator in the modeling-guided ablation group. The primary outcome was freedom from atrial tachyarrhythmias lasting longer than 30 s after a single procedure.
resultsDuring 31.5 ± 9.4 months, virtual ablation procedures were available in 95.2% of the patients (108/118). Clinical recurrence rate was significantly lower after a modeling-guided ablation than after an empirical ablation (20.8 vs. 40.0%, log-rank
conclusionAmong patients with persistent AF, the computational modeling-guided ablation was superior to the empirical catheter ablation regarding the rhythm outcome. CLINICAL
trial registrationThis study was registered with the ClinicalTrials.gov, number NCT02171364.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.