ArticleFrontiers in pharmacology2019
Striatal Cholinergic Interneurons: How to Elucidate Their Function in Health and Disease.
Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Comparative analysis of the cellular landscape in mammalian striatum.Nature communications · 2026Article
- An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement.bioRxiv : the preprint server for biology · 2026Article
- Calcium Dynamics in Astrocyte-Neuron Communication from Intracellular to Extracellular Signaling.Cells · 2025Review
- Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice.Nature communications · 2023Article
- The significance of micrographia as a clinical feature of Parkinson's disease and underlying pathophysiology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- The dopamine neuron synaptic map in the striatum.Cell reports · 2023Article
- Dopaminergic neurons are not a major Sonic hedgehog ligand source for striatal cholinergic or PV interneurons.iScience · 2022Article
- Three-Dimensional Spatial Analyses of Cholinergic Neuronal Distributions Across The Mouse Septum, Nucleus Basalis, Globus Pallidus, Nucleus Accumbens, and Caudate-Putamen.Neuroinformatics · 2022Article
- Changes in corticostriatal connectivity and striatal tissue iron associated with efficacy of clozapine for treatment‑resistant schizophrenia.Psychopharmacology · 2022Article
- Article
- Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain.Frontiers in neuroscience · 2022Article
- Reduced Axon Calibre in the Associative Striatum of theBrain sciences · 2021Article
- Article
- Review
- Striatal cholinergic transmission. Focus on nicotinic receptors' influence in striatal circuits.The European journal of neuroscience · 2021Review
- The Ventral Tegmental Area to Accumbens GABAergic Projection: Promoting Prediction or Engineering Extinction?Biological psychiatry · 2021Article
- Altered Cortical Cholinergic Network in Parkinson's Disease at Different Stage: A Resting-State fMRI Study.Frontiers in aging neuroscience · 2021Article
- Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson's Disease.Frontiers in neuroscience · 2021Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Striatal cholinergic interneurons (CINs) are the main source of acetylcholine in the striatum and are believed to play an important role in basal ganglia physiology and pathophysiology. The role of CINs in striatal function is known mostly from extracellular recordings of tonically active striatal neurons in monkeys, which are believed to correspond to CINs. Because these neurons transiently respond to motivationally cues with brief pauses, flanked by bursts of increased activity, they are classically viewed as key players in reward-related learning. However, CIN modulatory function within the striatal network has been mainly inferred from the action of acetylcholine agonists/antagonists or through CIN activation. These manipulations are far from recapitulating CIN activity in response to behaviorally-relevant stimuli. New technical tools such as optogenetics allow researchers to specifically manipulate this sparse neuronal population and to mimic their typical pause response. For example, it is now possible to investigate how short inhibition of CIN activity shapes striatal properties. Here, we review the most recent literature and show how these new techniques have brought considerable insights into the functional role of CINs in normal and pathological states, raising several interesting and novel questions. To continue moving forward, it is crucial to determine in detail CIN activity changes during behavior, particularly in rodents. We will also discuss how computational approaches combined with optogenetics will contribute to further our understanding of the CIN role in striatal circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.