ArticleFrontiers in aging neuroscience2019
Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis.Alzheimer's research & therapy · 2025Pooled it
- Genetic evidence for causal relationships between brain functional networks and domain-specific recovery after nondisabling ischemic stroke.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Deep adaptive learning predicts and diagnoses CSVD-related cognitive decline using radiomics from TNPJ digital medicine · 2025Article
- Neural Correlates and Adaptive Mechanisms in Vascular Cognitive Impairment: Exploration of a Structure-Function Coupling Network.CNS neuroscience & therapeutics · 2025Article
- Topological Perturbations in the Functional Connectome Support the Deficit/Non-deficit Distinction in Antipsychotic Medication-Naïve First Episode Psychosis Patients.Schizophrenia bulletin · 2024Article
- Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression.Brain and behavior · 2024Article
- Subsystem mechanisms of default mode network underlying white matter hyperintensity-related cognitive impairment.Human brain mapping · 2023Article
- Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study.Frontiers in aging neuroscience · 2023Article
- Altered brain networks and connections in chronic heart failure patients complicated with cognitive impairment.Frontiers in aging neuroscience · 2023Article
- Altered white matter structural connectivity in primary Sjögren's syndrome: a link-based analysis.Neuroradiology · 2022Article
- Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: A coronary artery risk development in young adults magnetic resonance imaging substudy.Human brain mapping · 2022Article
- Research progress on cognitive impairment and the expression of serum inflammatory markers in patients with white matter hyperintensities: a narrative review.Annals of translational medicine · 2022Review
- Impaired functional network properties contribute to white matter hyperintensity related cognitive decline in patients with cerebral small vessel disease.BMC medical imaging · 2022Article
- Altered gray matter structural covariance networks in drug-naïve and treated early HIV-infected individuals.Frontiers in neurology · 2022Article
- Age-Related Changes in Topological Properties of Individual Brain Metabolic Networks in Rats.Frontiers in aging neuroscience · 2022Article
- Rich-Club Organization Disturbances of the Individual Morphological Network in Subjective Cognitive Decline.Frontiers in aging neuroscience · 2022Article
- Alterations in resting-state functional connectivity in pediatric patients with tuberous sclerosis complex.Epilepsia open · 2021Article
- Disrupted Structural Brain Connectome Is Related to Cognitive Impairment in Patients With Ischemic Leukoaraiosis.Frontiers in human neuroscience · 2021Article
- Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification.Frontiers in aging neuroscience · 2020Article
- Impaired Structural Network Properties Caused by White Matter Hyperintensity Related to Cognitive Decline.Frontiers in neurology · 2020Article
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Authors and funding
11 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
White matter hyperintensity (WMH) is widely observed in the elderly population and serves as a key indicator of cognitive impairment (CI). However, the underlying mechanism remains to be elucidated. Herein, we investigated the topological patterns of resting state functional networks in WMH subjects and the relationship between the topological measures and CI. A graph theory-based analysis was employed in the resting-state functional magnetic resonance scans of 112 subjects (38 WMH subjects with cognitive impairment without dementia (CIND), 36 WMH subjects with normal cognition and 38 healthy controls (HCs), and we found that WMH-CIND subjects displayed decreased global efficiency at the levels of the whole brain, specific subnetworks [fronto-parietal network (FPN) and cingulo-opercular network (CON)] and certain nodes located in the FPN and CON, as well as decreased local efficiency in subnetworks. Our results demonstrated that nodal global efficiency in frontal and parietal regions mediated the impairment of information processing speed related to periventricular WMH (PWMH). Additionally, we performed support vector machine (SVM) analysis and found that altered functional efficiency can identify WMH-CIND subjects with high accuracy, sensitivity and specificity. These findings suggest impaired functional networks in WMH-CIND individuals and that decreased functional efficiency may be a feature of CI in WMH subjects.
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