Evidence map›Paper›PMID 31920598›Full record

ArticleFrontiers in human neuroscience2019

Interactive Effects of Racial Identity and Repetitive Head Impacts on Cognitive Function, Structural MRI-Derived Volumetric Measures, and Cerebrospinal Fluid Tau and Aβ.

Michael L Alosco, Yorghos Tripodis, Inga K Koerte, Jonathan D Jackson, Alicia S Chua, Megan Mariani, Olivia Haller, Éimear M Foley, Brett M Martin, Joseph Palmisano and 13 more

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Michael L AloscoBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Yorghos TripodisBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Inga K KoertePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Jonathan D JacksonCARE Research Center, Massachusetts General Hospital, Boston, MA, United States.
Alicia S ChuaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, United States.
Megan MarianiBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Olivia HallerBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Éimear M FoleyBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Brett M MartinBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Joseph PalmisanoBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Bhupinder SinghDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, United States.
Katie GreenPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Christian LepagePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Marc MuehlmannPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Nikos MakrisPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Robert C CantuBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Alexander P LinDepartment of Radiology, Center for Clinical Spectroscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Michael ColemanPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Jesse MezBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.
Sylvain BouixPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Robert A SternBoston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States.

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI ALEXANDER, GENE E · 2001 to 2020
$32.5M
Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
Chronic Traumatic Encephalopathy: Clinical Presentation and BiomarkersR01NS078337 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STERN, ROBERT A · 2011 to 2013
$2.0M
Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal ControlsK23NS102399 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ALOSCO, MICHAEL · 2018 to 2022
$793k
NIA NIH HHS P30 AG019610NINDS NIH HHS K23 NS102399NINDS NIH HHS R01 NS078337NINDS NIH HHS U01 NS093334
6 · The paper itself

Abstract

backgroundFactors of increased prevalence among individuals with Black racial identity (e.g., cardiovascular disease, CVD) may influence the association between exposure to repetitive head impacts (RHI) from American football and later-life neurological outcomes. Here, we tested the interaction between racial identity and RHI on neurobehavioral outcomes, brain volumetric measures, and cerebrospinal fluid (CSF) total tau (t-tau), phosphorylated tau (p-tau

methods68 symptomatic male former NFL players (ages 40-69;

resultsCompared to White former NFL players, Black participants were 4 years younger (

conclusionContinued research on racial neurological disparities could provide insight into risk factors for long-term neurological disorders associated with American football play.

Indexed as

American footballbiomarkerschronic traumatic encephalopathycognitive functionconcussionmagnetic resonance imagingracesubconcussion

Identifiers

PMID31920598
PMCPMC6933867

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.