ArticleFrontiers in human neuroscience2019
Neonatal White Matter Maturation Is Associated With Infant Language Development.
Article in Frontiers in human neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06292520 (ABLLS-R and Portage Guide in the Development of Receptive Language Skills in Children With Autism Spectrum Disorder.), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ABLLS-R and Portage Guide in the Development of Receptive Language Skills in Children With Autism Spectrum Disorder.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Postnatal distress, neonatal cerebellar myelination and neurodevelopmental outcomes at 18 months.Molecular psychiatry · 2026Article
- Tract-specific white matter microstructure associated with early cognitive development in infants.Neuroimage. Reports · 2026Article
- Cross-population white matter atlas creation for concurrent mapping of brain connections in neonates and adults with diffusion MRI tractography.Fundamental research · 2026Article
- Microstructure of white matter fiber tracts in infants with positional plagiocephaly.Pediatric radiology · 2026Article
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Utilizing functional neuroimaging to study early language development.Developmental cognitive neuroscience · 2025Review
- Early Memory and Executive Function as Predictors of Language Development: Evidence for Early Cognitive Foundations in a Taiwanese Cohort.Children (Basel, Switzerland) · 2025Article
- Prenatal Adversity and Neonatal White Matter Microstructure Independently Relate to Language Outcomes at Age 2 Years.The Journal of pediatrics · 2025Article
- The Effects of Prenatal Alcohol Exposure on Structural Brain Connectivity and Early Language Skills in a South African Birth Cohort.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Comparative profiling of white matter development in the human and mouse brain reveals volumetric deficits and delayed myelination in Angelman syndrome.Molecular autism · 2024Article
- Comparative profiling of white matter development in the human and mouse brain reveals volumetric deficits and delayed myelination in Angelman syndrome.Research square · 2024Article
- Longitudinal associations between language network characteristics in the infant brain and school-age reading abilities are mediated by early-developing phonological skills.Developmental cognitive neuroscience · 2024Article
- White matter development and language abilities during infancy in autism spectrum disorder.Molecular psychiatry · 2024Article
- Longitudinal associations between language network characteristics in the infant brain and school-age reading abilities are mediated by early-developing phonological skills.bioRxiv : the preprint server for biology · 2024Article
- Prenatal tobacco and alcohol exposure, white matter microstructure, and early language skills in toddlers from a South African birth cohort.Frontiers in integrative neuroscience · 2024Article
- Neural Network Functional Interactions Mediate or Suppress White Matter-Emotional Behavior Relationships in Infants.Biological psychiatry · 2023Article
- Language Experience during Infancy Predicts White Matter Myelination at Age 2 Years.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Language input in late infancy scaffolds emergent literacy skills and predicts reading related white matter development.Frontiers in human neuroscience · 2022Article
- Diffusion Tensor Based White Matter Tract Atlases for Pediatric Populations.Frontiers in neuroscience · 2022Article
- Prediction of autism spectrum disorder diagnosis using nonlinear measures of language-related EEG at 6 and 12 months.Journal of neurodevelopmental disorders · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundWhile neonates have no sophisticated language skills, the neural basis for acquiring this function is assumed to already be present at birth. Receptive language is measurable by 6 months of age and meaningful speech production by 10-18 months of age. Fiber tracts supporting language processing include the corpus callosum (CC), which plays a key role in the hemispheric lateralization of language; the left arcuate fasciculus (AF), which is associated with syntactic processing; and the right AF, which plays a role in prosody and semantics. We examined if neonatal maturation of these fiber tracts is associated with receptive language development at 12 months of age.
methodsDiffusion-weighted imaging (DWI) was performed in 86 infants at 26.6 ± 12.2 days post-birth. Receptive language was assessed
resultsAfter multiple comparisons correction, higher neonatal FA was positively associated with receptive language at 12 months of age within the genu (
conclusionMicrostructural development of the CC and the AF in the newborn is associated with receptive language at 12 months of age, demonstrating that interindividual variation in white matter microstructure is relevant for later language development, and indicating that the neural foundation for language processing is laid well ahead of the majority of language acquisition. This suggests that some origins of impaired language development may lie in the intrauterine and potentially neonatal period of life. Understanding how interindividual differences in neonatal brain maturity relate to the acquisition of function, particularly during early development when the brain is in an unparalleled window of plasticity, is key to identifying opportunities for harnessing neuroplasticity in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.