ArticleFrontiers in behavioral neuroscience2019
Male C57BL6/N and C57BL6/J Mice Respond Differently to Constant Light and Running-Wheel Access.
Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Forsythoside A attenuates metabolic dysfunction in type 2 diabetic mice by inhibiting the MAPK and activating the Nrf2 signalling pathways.Arhiv za higijenu rada i toksikologiju · 2026Article
- Review
- The Effects of Constant Light and Running-Wheel Access in Middle-Aged Female C57BL6/J Mice.Sleep science (Sao Paulo, Brazil) · 2025Article
- Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice.Molecular autism · 2025Article
- Consumption of dopamine receptor 1 agonist SKF-38393 reduces constant-light-induced hyperactivity, depression-like, and anxiety-like behaviors in a sex specific manner in C57BL/6J mice.Frontiers in behavioral neuroscience · 2025Article
- Sex-dependent effects of chronic jet lag on circadian rhythm and metabolism in mice.Biology of sex differences · 2024Article
- Turn off that night light! Light-at-night as a stressor for adolescents.Frontiers in neuroscience · 2024Review
- Effects of home-cage elevation on behavioral tests in mice.Brain and behavior · 2023Article
- Cyfip2 allelic variation in C57BL/6J and C57BL/6NJ mice alters free-choice ethanol drinking but not binge-like drinking or wheel-running activity.Alcohol, clinical & experimental research · 2023Article
- Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets.Cancer metastasis reviews · 2023Review
- Chronic blue light-emitting diode exposure harvests gut dysbiosis related to cholesterol dysregulation.Frontiers in cellular and infection microbiology · 2023Article
- Article
- A Phenomenological Mouse Circadian Pacemaker Model.Journal of biological rhythms · 2022Article
- Distinct Age-Specific Effects on Olfactory Associative Learning in C57BL/6 Substrains.Frontiers in behavioral neuroscience · 2022Article
- Phenotyping spontaneous locomotor activity in inbred and outbred mouse strains by using Digital Ventilated Cages.Lab animal · 2021Article
- Substrains matter in phenotyping of C57BL/6 mice.Experimental animals · 2021Review
- Changes in sleep EEG with aging in humans and rodents.Pflugers Archiv : European journal of physiology · 2021Review
- Circadian rhythms in the mouse reproductive axis during the estrous cycle and pregnancy.Journal of neuroscience research · 2021Article
- Substrain specific behavioral responses in male C57BL/6N and C57BL/6J mice to a shortened 21-hour day and high-fat diet.Chronobiology international · 2020Article
- Wheel-Running Behavior Is Negatively Impacted by Zinc Administration in a Novel Dual Transgenic Mouse Model of AD.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have shown that exposure to circadian disruption produces negative effects on overall health and behavior. More recent studies illustrate that strain differences in the behavioral and physiological responses to circadian disruption exist, even if the strains have similar genetic backgrounds. As such, we investigated the effects of constant room-level light (LL) with running-wheel access on the behavior and physiology of male C57BL6/J from Jackson Laboratories and C57BL6/N from Charles River Laboratories mice. Mice were exposed to either a 12:12 light-dark (LD) cycle or LL and given either a standard home cage or a cage with a running-wheel. Following 6 weeks of LD or LL, their response to behavioral assays (open-field, light-dark box, novel object) and measures of metabolism were observed. Under standard LD, C57BL6/J mice exhibited increased locomotor activity and reduced exploratory behavior compared to C57BL6/N mice. In LL, C57BL6/J mice had greater period lengthening and increased anxiety, while C57BL6/N mice exhibited increased weight gain and no change in exploratory behavior. C57BL6/J mice also decreased exploration with running-wheel access while C57BL6/N mice did not. These results further demonstrate that C57BL/6 substrains exhibit different behavioral and physiological responses to circadian disruption and wheel-running access.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.