ArticleFrontiers in neuroscience2019
Adaptation of Respiratory-Related Brain Regions to Long-Term Hypercapnia: Focus on Neuropeptides in the RTN.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Characterisation of putative retrotrapezoid nucleus (RTN) chemoreceptor neurons in the adult human brainstem.Brain structure & function · 2025Article
- Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025Review
- Galaninergic and hypercapnia-activated neuronal projections to the ventral respiratory column.Brain structure & function · 2024Article
- Whole-brain analysis of CObioRxiv : the preprint server for biology · 2023Article
- Chronic moderate hypercapnia suppresses ventilatory responses to acute CO<sub>2</sub> challenges.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Ventilatory neural drive in chronically hypercapnic patients with COPD: effects of sleep and nocturnal noninvasive ventilation.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Review: Neuropathology findings in autonomic brain regions in SUDEP and future research directions.Autonomic neuroscience : basic & clinical · 2021Review
- Air Hunger: A Primal Sensation and a Primary Element of Dyspnea.Comprehensive Physiology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term hypercapnia is associated with respiratory conditions including obstructive sleep apnea, chronic obstructive pulmonary disease and obesity hypoventilation syndrome. Animal studies have demonstrated an initial (within hours) increase in ventilatory drive followed by a decrease in this response over the long-term (days-weeks) in response hypercapnia. Little is known about whether changes in the central respiratory chemoreflex are involved. Here we investigated whether central respiratory chemoreceptor neurons of the retrotrapezoid nucleus (RTN), which project to the respiratory pattern generator within the ventral respiratory column (VRC) have a role in the mechanism of neuroplasticity associated with long-term hypercapnia. Adult male C57BL/6 mice (
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