Evidence map›Paper›PMID 31920504›Full record

ArticleFrontiers in neuroscience2019

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils.

Yann Fichou, Zachary R Oberholtzer, Hoang Ngo, Chi-Yuan Cheng, Timothy J Keller, Neil A Eschmann, Songi Han

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Riboregulation: a non-canonical tau function.Molecular neurodegeneration · 2026
    Review
  3. Article
  4. Article
  5. DnaJB1 chaperone inhibits tau aggregation by recognizing its N-terminus.bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Water-directed pinning is key to tau prion formation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
  10. Chemical Synthesis Reveals Pathogenic Role ofJournal of the American Chemical Society · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Post-Translational Modifications Control Phase Transitions of Tau.bioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Mechanisms and pathology of protein misfolding and aggregation.Nature reviews. Molecular cell biology · 2023
    Review
  17. Mapping the configurational landscape and aggregation phase behavior of the tau protein fragment PHF6.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yann FichouDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.
Zachary R OberholtzerDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.
Hoang NgoDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.
Chi-Yuan ChengDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.
Timothy J KellerDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.
Neil A EschmannDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.
Songi HanDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.
University of California, Santa Barbara · US

Funding

Molecular Basis of the Tau Aggregation PathwayR01AG056058 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Songi Han, KENNETH Stephen KOSIK · 2017 to 2026
$6.4M
NIA NIH HHS R01 AG056058
6 · The paper itself

Abstract

The aggregation of the human tau protein into neurofibrillary tangles is directly diagnostic of many neurodegenerative conditions termed tauopathies. The species, factors and events that are responsible for the initiation and propagation of tau aggregation are not clearly established, even in a simplified and artificial

Indexed as

aggregation seedingcofactorsconformational transformationprotein aggregationtau oligomerstauopathiestau protein

Identifiers

PMID31920504
PMCPMC6923735
OpenAlexW2991423684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.