ArticleFrontiers in neuroscience2019
Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Sleep Disorders and Cognitive Dysfunctions in Parkinson's Disease: A Meta-Analytic Study.Neuropsychology review · 2021Pooled it
- Altered Functional Connectivity and Small-World Network Properties in MDD With Daytime Sleepiness: Implications for Anhedonia.Depression and anxiety · 2026Article
- Clinical and Functional Connectivity Markers in Prediction of Hallucinations in Parkinson's Disease.CNS neuroscience & therapeutics · 2025Article
- A Cross Sectional and Longitudinal Assessment of Neuropsychiatric Symptoms and Brain Functional Connectivity in Patients With Mild Cognitive Impairment, Cerebrovascular Disease and Parkinson Disease.International journal of geriatric psychiatry · 2025Article
- Subregion-specific associations of the basal forebrain with sleep and cognition in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson's disease with excessive daytime sleepiness.Frontiers in aging neuroscience · 2025Article
- Drooling disrupts the brain functional connectivity network in Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Altered dynamic functional network connectivity in drug-naïve Parkinson's disease patients with excessive daytime sleepiness.Frontiers in aging neuroscience · 2023Article
- Abnormalities in the Fractional Amplitude of Low-Frequency Fluctuation and Functional Connectivity in Parkinson's Disease With Excessive Daytime Sleepiness.Frontiers in aging neuroscience · 2022Article
- Functional Connectome in Parkinson's Disease and Parkinsonism.Current neurology and neuroscience reports · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD.
methodsEarly PD patients comprising eighty-one patients without EDS (EDS-) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal ganglia networks were compared between the EDS+ and EDS- groups. Correlations between network connectivity and the severity of EDS were investigated through linear regression.
resultsEDS+ patients displayed a trend of increased network connectivity of the posterior DMN (pDMN). A significant positive correlation was found between connectivity of the ventromedial prefrontal cortex in the pDMN and ESS.
conclusionEDS+ patients are likely to display increased activation in the DMN, suggesting neural compensation in early PD or impaired attentiveness due to mechanisms such as mind-wandering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.