ACOEC-FD: Ant Colony Optimization for Learning Brain Effective Connectivity Networks From Functional MRI and Diffusion Tensor Imaging.

Identifying brain effective connectivity (EC) networks from neuroimaging data has become an effective tool that can evaluate normal brain functions and the injuries associated with neurodegenerative diseases. So far, there are many methods used to identify EC networks. However, most of the research currently focus on learning EC networks from single modal imaging data such as functional magnetic resonance imaging (fMRI) data. This paper proposes a new method, called ACOEC-FD, to learn EC networks from fMRI and diffusion tensor imaging (DTI) using ant colony optimization (ACO). First, ACOEC-FD uses DTI data to acquire some positively correlated relations among regions of interest (ROI), and takes them as anatomical constraint information to effectively restrict the search space of candidate arcs in an EC network. ACOEC-FD then achieves multi-modal imaging data integration by incorporating anatomical constraint information into the heuristic function of probabilistic transition rules to effectively encourage ants more likely to search for connections between structurally connected regions. Through simulation studies on generated datasets and real fMRI-DTI datasets, we demonstrate that the proposed approach results in improved inference results on EC compared to some methods that only used fMRI data.