Evidence map›Paper›PMID 31920403›Full record

ArticleHIV/AIDS (Auckland, N.Z.)2019

Opportunistic Respiratory Infections in HIV Patients Attending Sukraraj Tropical and Infectious Diseases Hospital in Kathmandu, Nepal.

Rooku Kc, Sadiksha Adhikari, Anup Bastola, Lina Devkota, Parmananda Bhandari, Prabina Ghimire, Bipin Adhikari, Komal Raj Rijal, Megha Raj Banjara, Prakash Ghimire

Open access · goldAbstract read
In one paragraph

Article in HIV/AIDS (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Biofilm-ProducingHIV/AIDS (Auckland, N.Z.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Rooku Kc *Central Department of Microbiology, Tribhuvan University, Kathmandu, Nepal.
Sadiksha Adhikari *Central Department of Microbiology, Tribhuvan University, Kathmandu, Nepal.
Anup BastolaSukraraj Tropical and Infectious Diseases Hospital, Kathmandu, Nepal.
Lina DevkotaSukraraj Tropical and Infectious Diseases Hospital, Kathmandu, Nepal.ORCID 0000-0002-6717-2136
Parmananda BhandariSukraraj Tropical and Infectious Diseases Hospital, Kathmandu, Nepal.
Prabina GhimireNepal Medical College, Jorpati, Kathmandu, Nepal.
Bipin AdhikariCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-8981-3910
Komal Raj RijalCentral Department of Microbiology, Tribhuvan University, Kathmandu, Nepal.ORCID 0000-0001-6281-8236
Megha Raj BanjaraCentral Department of Microbiology, Tribhuvan University, Kathmandu, Nepal.
Prakash GhimireCentral Department of Microbiology, Tribhuvan University, Kathmandu, Nepal.ORCID 0000-0003-2503-412X
Tribhuvan University · NPSukraraj Tropical & Infectious Disease Hospital · NPNepal Medical College Teaching Hospital · NPUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOpportunistic bacterial and fungal infections are the major cause of morbidity and mortality among immune suppressed HIV-positive patients. The main objective of this study was to determine bacterial and fungal organisms causing respiratory infections and their susceptibility to commonly prescribed antimicrobials among HIV patients attending a tertiary infectious disease hospital in Kathmandu.

methodsSputum samples were collected from the HIV-positive patients attending Sukraraj Tropical and Infectious Disease Hospital (STIDH) from August 2017 to March 2018. A total of 100 sputum samples were cultured on conventional bacterial and fungal culture media. Bacterial and fungal isolates were identified based on their colony characteristics, microscopic morphology and various biochemical tests. Antibiotic susceptibility test (AST) of bacterial isolates was performed by modified Kirby Bauer disc diffusion method.

resultsOut of 100 sputum samples cultured, 24% (n=24) showed bacterial growth, 42% (n=42) showed fungal growth and 10% (n=10) had both bacterial and fungal growth. Among bacteria, 91.6% (n=22) were monomicrobial and 8.4% (n=2) were polymicrobial in growth, of which,

conclusionHIV-positive patients with a CD4 count less than 200 cells/µL are more vulnerable to opportunistic infections of bacterial and fungal origin. Early isolation, identification and appropriate treatment can reduce mortality due to co-infections. Routine screening of opportunistic pathogens is critical to contain the disease progression.

Indexed as

bacterial and fungal infectionCD4HIVopportunistic infections

Identifiers

PMID31920403
PMCPMC6939395
OpenAlexW2997330464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.