ArticleJournal of pain research2019
A Pleasant Sensation Evoked by Knee or Hand Icing Influences the Effect on Pain Intensity in Patients After Total knee Arthroplasty: A Prospective, Randomized, Cross-Over Study.
Article in Journal of pain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical practice guideline for physical therapist management of total knee arthroplasty: revision 2026.Physical therapy · 2026Guideline
- Cryotherapy following total knee replacement.The Cochrane database of systematic reviews · 2023Pooled it
- Effectiveness and methods of cryotherapy in reducing swelling after total knee arthroplasty: A systematic review on randomized controlled trials.Nursing open · 2023Pooled it
- Cryotherapy and thermotherapy in the management of osteoarthritis and rheumatoid arthritis: A comprehensive review.Fundamental research · 2025Review
- The Effect of Video-Based Education on Activities of Daily Living and Wound Healing of Patients with Total Hip Replacement: Randomised Controlled Trials.Nursing reports (Pavia, Italy) · 2025Article
- Mirabilite with Ice Pack after Total Knee Arthroplasty: A Randomized Controlled Trial Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCold therapy on the operated area after surgery is often used as an analgesic and to reduce pain, swelling, and increase range of motion. However, evidence to support the results of cold therapy is still scarce and the mechanism underlying its effectiveness remains unclear. The present study aimed to investigate whether a pleasant sensation evoked by icing the treated knee or a site distant from the treated site (the hand) influenced the acute effect on pain intensity in patients who have undergone total knee arthroplasty (TKA). PATIENTS AND
methodsA total of 37 patients with knee OA who underwent TKA were enrolled in this study. This prospective, randomized, cross-over study was performed for 2 days consecutively between days 8 and 15 postoperatively. Cold pack was placed on the anterior surface of the treated knee and palm for 10 mins, respectively. The main primary outcomes were the intensity of knee pain during maximal passive knee flexion.
resultsThe two-way ANOVA showed significance only in the main effect of a pleasant sensation (F = 11.3, p = 0.001), but not in the icing site (F = 0.005, p = 0.94) and interaction (F = 0.65, p = 0.42).
conclusionThis study shows that a pleasant sensation evoked by knee or hand icing influenced the effect on pain intensity during maximal knee flexion in patients after TKA. Even if knee icing has no effect on pain and evokes no pleasant sensation, it may be worthwhile to conduct hand icing to reduce pain.
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