Evidence map›Paper›PMID 31920348›Full record

ArticleInfection and drug resistance2019

In vitro Antibacterial Activity of Isopropoxy Benzene Guanidine Against Multidrug-Resistant

Xiufeng Zhang, Dongdong Han, Pengfei Pei, Jie Hao, Yixing Lu, Peng Wan, Xianfeng Peng, Weibiao Lv, Wenguang Xiong, Zhenling Zeng

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Global trends in antimicrobial resistance ofFrontiers in pharmacology · 2025
    Pooled it
  2. Isopropoxy Benzene Guanidine AmelioratesInternational journal of molecular sciences · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Frontiers in microbiology · 2022
    Article
  9. Isopropoxy Benzene Guanidine KillsFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xiufeng ZhangNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, People's Republic of China.
Dongdong HanNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, People's Republic of China.
Pengfei PeiNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, People's Republic of China.
Jie HaoNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, People's Republic of China.
Yixing LuNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, People's Republic of China.
Peng WanNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, People's Republic of China.
Xianfeng PengGuangzhou Insighter Biotechnology Co., Ltd, Guangzhou 510642, People's Republic of China.ORCID 0000-0002-2547-7353
Weibiao LvDepartment of Clinical Laboratory, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan 528000, People's Republic of China.
Wenguang XiongNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, People's Republic of China.
Zhenling ZengNational Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, South China Agricultural University, Guangzhou 510642, People's Republic of China.
South China Agricultural University · CNInsight (China) · CNThe First People's Hospital of Shunde · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBacterial infections cause a serious public health crisis due to the emergence of resistance towards multiple conventional antibacterial drugs. In particular, multidrug-resistant (MDR) PURPOSE: Here we investigated the antimicrobial activity of a new substituted benzene guanidine analog, isopropoxy benzene guanidine, against MATERIAL AND

methodsThe isopropoxy benzene guanidine was synthesized by Guangzhou Insighter Biotechnology Co., Ltd and tested on both reference bacterial strain and 32 clinical MDR

resultsIsopropoxy benzene guanidine exhibited potent bactericidal activity against both reference strain and MDR

conclusionThe present study highlights the potent bactericidal activity of isopropoxy benzene guanidine on

Indexed as

3bactericidal activitycell membrane potentialDiOC2isopropoxy benzene guanidineMDR Enterococci

Identifiers

PMID31920348
PMCPMC6934121
OpenAlexW2995441079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.