Evidence map›Paper›PMID 31920316›Full record

ArticleNeuropsychiatric disease and treatment2019

Managing Functional Neurological Disorders: Protocol of a Cohort Study on Psychogenic Non-Epileptic Seizures Study.

Hamada Hamid Altalib, Daniela Galluzzo, Stephanie Argraves, Joseph Goulet, Yarden Bornovski, Kei-Hoi Cheung, Ebony Jackson-Shaheed, Benjamin Tolchin, Brenda T Fenton, Mary Jo Pugh

Open access · goldAbstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hamada Hamid AltalibVA Connecticut Healthcare System, West Haven, CT, USA.
Daniela GalluzzoWestchester Medical Center, Westchester, NY, USA.ORCID 0000-0002-4059-9818
Stephanie ArgravesVA Connecticut Healthcare System, West Haven, CT, USA.
Joseph GouletVA Connecticut Healthcare System, West Haven, CT, USA.ORCID 0000-0002-0842-804X
Yarden BornovskiVA Connecticut Healthcare System, West Haven, CT, USA.
Kei-Hoi CheungVA Connecticut Healthcare System, West Haven, CT, USA.ORCID 0000-0001-6432-9372
Ebony Jackson-ShaheedVA Connecticut Healthcare System, West Haven, CT, USA.
Benjamin TolchinVA Connecticut Healthcare System, West Haven, CT, USA.ORCID 0000-0002-9099-0022
Brenda T FentonVA Connecticut Healthcare System, West Haven, CT, USA.
Mary Jo PughUniversity of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-4196-7763
VA Connecticut Healthcare System · USYale University · USUniversity of Utah · USWestchester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFunctional neurological disorders (FNDs) are neurological symptoms that cannot be explained by an underlying neurological lesion or other medical illness and that do not have clear neuropathological correlates. Psychogenic non-epileptic seizures (PNES) are a common and highly disabling form of FND, characterized by paroxysmal episodes of involuntary movements and altered consciousness that can appear clinically similar to epileptic seizures. PNES are unique among FNDs in that they are diagnosed by video electroencephalographic (VEEG), a well-established biomarker for the disorder. The course of illness and response to treatment of PNES remain controversial. This study aims to describe the epidemiology of PNES in the Department of Veterans Affairs Healthcare System (VA), evaluate outcomes of veterans offered different treatments, and compare models of care for PNES.

methodsThis electronic health record (EHR) cohort study utilizes an informatics search tool and a natural language processing algorithm to identify cases of PNES nationally. We will use VA inpatient, outpatient, pharmacy, and chart abstraction data across all 170 medical centers to identify cases in fiscal years 2002-2018. Outcome measurements such as seizure frequency, emergency room visits, hospital admissions, suicide-related behavior, and the utilization of psychotherapy prior to and after PNES diagnosis will be used to assess the effectiveness of models of care. DISCUSSION: This study will describe the risk factors and course of treatment of a large cohort of people with PNES. Since PNES are cared for by a variety of different modalities, treatment orientations, and models of care, effectiveness outcomes such as seizure outcomes and utilization of emergency visits for seizures will be assessed. Outcome measurements such as seizure frequency, emergency room visits, hospital admissions, suicide-related behavior, and psychotherapy prior to and after PNES diagnosis will be used to assess the effectiveness of models of care.

Indexed as

EHRelectronic health recordFNDfunctional neurological disordersPNESpsychogenic non-epileptic seizuresVAVeterans Administration

Identifiers

PMID31920316
PMCPMC6939176
OpenAlexW2998035357

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.