ReviewJournal of anaesthesiology, clinical pharmacology
Opioid free onco-anesthesia: Is it time to convict opioids? A systematic review of literature.
Review in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Opioid-Free Anesthesia Improved the Quality of Recovery After Thyroidectomy Through Pre-Emptive and Preventive Analgesia: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Role of Thoracic Epidural Anesthesia in Providing Adequate Intraoperative and Postoperative Opioid-free Analgesia for Breast Cancer Surgeries.Annals of African medicine · 2026Observational
- Erector spinae plane block with bupivacaine contributes to intraoperative opioid sparing but provides limited postoperative pain control in cats undergoing elective ovariohysterectomy under continuous propofol infusion.Veterinary research communications · 2026Article
- Trajectories of Pain in Low-Opioid and Opioid-Based Postoperative Analgesia in Older Patients-Perioperative Clinical Study.Journal of clinical medicine · 2025Article
- Sex-Related Analgesic Effects of Opioid-Based Anesthesia and Low-Opioid Anesthesia with Non-Opioid Postoperative Analgesia-A Clinical Observational Study.Journal of clinical medicine · 2025Article
- Risk of infections among persons treated with opioids for chronic pain: a systematic review and meta-analysis protocol.BMJ open · 2024Article
- The Surgical Stress Response and Anesthesia: A Narrative Review.Journal of clinical medicine · 2024Review
- Postoperative opioid-free analgesia in dogs undergoing tibial plateau leveling osteotomy: a feasibility study.Frontiers in veterinary science · 2024Article
- Are There Any Advantages of the Low Opioid Anaesthesia and Non-Opioid Postoperative Analgesia Protocol: A Clinical Observational Study.Journal of pain research · 2024Article
- Patient-reported nausea after implementation of an enhanced recovery after surgery protocol for gynae-oncology patients.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Article
- Can Opioid-Free Anaesthesia Be Personalised? A Narrative Review.Journal of personalized medicine · 2023Review
- A retrospective investigation of the relationship between neuroblastoma response to anti-GD2 monoclonal antibodies and exposure to opioids for pain management.Pediatric blood & cancer · 2023Article
- Article
- Tissue Regeneration: The Dark Side of Opioids.International journal of molecular sciences · 2021Review
- Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review.Plastic and reconstructive surgery. Global open · 2021Article
- Pain relief is not optional - Choose wisely.Indian journal of anaesthesia · 2020Article
- Perioperative opioids: Are they indispensable?Journal of anaesthesiology, clinical pharmacologyArticle
- Comparison of opioid-free anesthesia with opioid-based anesthesia in neonates and infants undergoing laparoscopic or endoscopic surgeries: A randomized controlled trial.Saudi journal of anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epidemic of opioid crisis started getting recognised as a public health emergency in view of increasing opioid-related deaths occurring due to undetected respiratory depression. Prescribing opioids at discharge has become an independent risk factor for chronic opioid use, following which, prescription practices have undergone a radical change. A call to action has been voiced recently to end the opioid epidemic although with the pain practitioners still struggling to make opioids readily available. American Society of Anesthesiologist (ASA) has called for reducing patient exposure to opioids in the surgical setting. Opioid sparing strategies have emerged embracing loco-regional techniques and non-opioid based multimodal pain management whereas opioid free anesthesia is the combination of various opioid sparing strategies culminating in complete elimination of opioid usage. The movement away from opioid usage perioperatively is a massive but necessary shift in anesthesia which has rationalised perioperative opioid usage. Ideal way moving forward would be to adapt selective low opioid effective dosing which is both procedure and patient specific while reserving it as rescue analgesia, postoperatively. Many unknowns persist in the domain of immunologic effects of opioids, as complex interplay of factors gets associated during real time surgery towards outcome. At present it would be too premature to conclude upon opioid-induced immunosuppression from the existing evidence. Till evidence is established, there are no recommendations to change current clinical practice. At the same time, consideration for multimodal opioid sparing strategies should be initiated in each patient undergoing surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.