Evidence map›Paper›PMID 31920150›Full record

ArticleAutophagy2020

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein.

Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, Guido Kroemer, Daniel J Klionsky, Herbert J Zeh, Rui Kang, Jing Wang, Daolin Tang

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 408 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
408citing papers in PubMed, 1 pooled it
42.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

408 citing papers in PubMed, 1 synthesis or guideline pooled it, 570 citations in OpenAlex.

  1. Ferroptosis and tumor immunity.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. The Emerging Role of Ferroptosis in Pediatric Cancer Biology and Therapy.International journal of molecular sciences · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

348 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Enyong DaiDepartment of Oncology and Hematology, China-Japan Union Hospital of Jilin University , Changchun, Jilin, China.
Leng HanDepartment of Oncology and Hematology, China-Japan Union Hospital of Jilin University , Changchun, Jilin, China.
Jiao LiuThe Third Affiliated Hospital, Guangzhou Medical University , Guangzhou, Guangdong, China.
Yangchun XieDepartment of Oncology, The Second Xiangya Hospital of Central South University , Changsha, Hunan, China.
Guido KroemerEquipe Labellisée Par La Ligue Contre Le Cancer, Université De Paris, Sorbonne Université, INSERM U1138, Centre De Recherche Des Cordeliers , Paris, France.ORCID 0000-0002-9334-4405
Daniel J KlionskyLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor, Michigan, USA.ORCID 0000-0002-7828-8118
Herbert J ZehDepartment of Surgery, UT Southwestern Medical Center , Dallas, Texas, USA.
Rui KangDepartment of Surgery, UT Southwestern Medical Center , Dallas, Texas, USA.
Jing WangDepartment of Respiratory Medicine, China-Japan Union Hospital of Jilin University , Changchun, Jilin, China.
Daolin TangThe Third Affiliated Hospital, Guangzhou Medical University , Guangzhou, Guangdong, China.
Jilin University · CNSouthwestern Medical Center · USThird Affiliated Hospital of Guangzhou Medical University · CNCentral South University · CNKarolinska University Hospital · SEUniversity of Michigan · US

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
The Pancreatic Cancer MicroenvironmentR01CA211070 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI KANG, RUI · 2017 to 2023
$1.4M
EPA EP-C-16-014NCI NIH HHS R01 CA211070NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAutophagyCarcinoma, Pancreatic DuctalCell ProliferationCell Transformation, NeoplasticFemaleFerroptosisGene Expression Regulation, NeoplasticHumansLeukocytes, MononuclearMaleMiddle AgedPancreasPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)KRAS protein, humanProto-Oncogene Proteins p21(ras)autophagyDAMPexosomesferroptosisKRASmacrophage

Identifiers

PMID31920150
PMCPMC7595620
OpenAlexW2999138070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.