ArticlePediatric obesity2020
In utero exposure to gestational diabetes mellitus and cardiovascular risk factors in youth: A longitudinal analysis in the EPOCH cohort.
Article in Pediatric obesity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gestational diabetes mellitus and development of intergenerational overall and subtypes of cardiovascular diseases: a systematic review and meta-analysis.Cardiovascular diabetology · 2024Pooled it
- Prenatal factors shaping adolescent cardiovascular function and cardiometabolic risk trajectories.Frontiers in pediatrics · 2026Review
- Infant body composition trajectories differ by in utero exposure to gestational diabetes mellitus: a prospective cohort from birth to 12 months.The American journal of clinical nutrition · 2025Article
- Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring.The Journal of clinical investigation · 2024Article
- Gestational Diabetes Mellitus and Its Implications across the Life Span.Diabetes & metabolism journal · 2023Review
- Hyperglycaemia in pregnancy and offspring blood pressure: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2023Review
- Effect of Gestational Diabetes Mellitus on the Growth, Development, and Stem Cells of Offspring.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles.Cardiovascular diabetology · 2022Review
- Endotoxin Biomarkers Are Associated With Adiposity and Cardiometabolic Risk Across 6 Years of Follow-up in Youth.The Journal of clinical endocrinology and metabolism · 2022Article
- Hyperglycemia First Detected in Pregnancy in South Africa: Facts, Gaps, and Opportunities.Frontiers in clinical diabetes and healthcare · 2022Review
- How does exposure to overnutrition in utero lead to childhood adiposity? Testing the insulin hypersecretion hypothesis in the EPOCH cohort.Diabetologia · 2021Article
- Genetic Interactions with Intrauterine Diabetes Exposure in Relation to Obesity: The EPOCH and Project Viva Studies.Pediatric reports · 2021Article
- Trends in prevalence of gestational diabetes mellitus in Zhejiang Province, China, 2016-2018.Nutrition & metabolism · 2021Article
- Association Analysis in Children Born from Normal and Complicated Pregnancies-Cardiovascular Disease Associated microRNAs and the Incidence of Prehypertension/Hypertension, Overweight/Obesity, Valve Problems and Heart Defects.International journal of molecular sciences · 2020Article
- Sex-Specific Metabolite Biomarkers of NAFLD in Youth: A Prospective Study in the EPOCH Cohort.The Journal of clinical endocrinology and metabolism · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo examine associations of maternal gestational diabetes mellitus (GDM) with offspring cardiovascular biomarkers from late childhood through adolescence.
methodsWe used mixed effects linear regression models to examine associations of maternal GDM (n = 92 cases of 597) with average offspring levels of serum lipids (total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides) and systolic blood pressure (SBP) across two research visits spanning approximately 10.6 and 16.9 years of age. In sex-stratified analysis, we evaluated the impact of adjustment for sociodemographic characteristics, pubertal status, physical activity and total energy intake, maternal body mass index (BMI), GDM treatment, and child's BMI.
resultsAfter adjusting for child's age, pubertal status, race/ethnicity, and maternal education and smoking, GDM exposure was associated with higher total (0.38 [95% CI, 0.16-0.61] mmol/L) and LDL cholesterol (0.34 [95% CI, 0.14-0.53] mmol/L) in girls. These estimates were robust to adjustment for lifestyle characteristics and maternal BMI but were attenuated after accounting for GDM treatment with no appreciable change following further adjustment for current BMI. In boys, maternal GDM corresponded with 4.50 (1.90-7.10) mmHg higher SBP. This association persisted after accounting for sociodemographic/lifestyle characteristics, maternal BMI, and GDM treatment but was attenuated after adjusting for current BMI.
conclusionsMaternal GDM is related to offspring lipid profile and SBP in a sex-specific manner.
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