ArticleMolecular plant pathology2020
Xanthomonas campestris sensor kinase HpaS co-opts the orphan response regulator VemR to form a branched two-component system that regulates motility.
Article in Molecular plant pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- DrdR Negatively Modulates the Expression of Flagellar Genes via Interaction With FleQ in Xanthomonas campestris.Molecular plant pathology · 2026Article
- GpaR Drives Type III Secretion and Virulence Through Direct Activation of the HrpG-HrpX Cascade in Xanthomonas oryzae pv. oryzicola.Molecular plant pathology · 2026Article
- Tandem receiver domain response regulator DrdR modulates swarming by controlling PilB/PilT activity inmLife · 2026Article
- Functional study of FleQ reveals the co-regulation ofiScience · 2025Article
- Xanthomonas oryzae Orphan Response Regulator EmvR Is Involved in Virulence, Extracellular Polysaccharide Production and Cell Motility.Molecular plant pathology · 2025Article
- The pathogenicity-associated regulators participating in the regulatory cascade for RaxSTAB and RaxX in Xanthomonas oryzae pv. oryzae.Molecular plant pathology · 2024Article
- Xanthomonas campestris VemR enhances the transcription of the T3SS key regulator HrpX via physical interaction with HrpG.Molecular plant pathology · 2023Article
- Anti-Virulence Strategy of Novel Dehydroabietic Acid Derivatives: Design, Synthesis, and Antibacterial Evaluation.International journal of molecular sciences · 2023Article
- Transcriptional regulator Sar regulates the multiple secretion systems in Xanthomonas oryzae.Molecular plant pathology · 2023Article
- HpaP divergently regulates the expression of hrp genes in Xanthomonas oryzae pathovars oryzae and oryzicola.Molecular plant pathology · 2023Article
- The MinCDE Cell Division System Participates in the Regulation of Type III Secretion System (T3SS) Genes, Bacterial Virulence, and Motility inMicroorganisms · 2022Article
- McvR, a single domain response regulator regulates motility and virulence in the plant pathogen Xanthomonas campestris.Molecular plant pathology · 2022Article
- The Methyltransferase HemK Regulates the Virulence and Nutrient Utilization of the Phytopathogenic BacteriumInternational journal of molecular sciences · 2022Article
- The RavA/VemR two-component system plays vital regulatory roles in the motility and virulence of Xanthomonas campestris.Molecular plant pathology · 2022Article
- Article
- A HU-like protein is required for full virulence in Xanthomonas campestris pv. campestris.Molecular plant pathology · 2021Article
- Xanthomonas campestris sensor kinase HpaS co-opts the orphan response regulator VemR to form a branched two-component system that regulates motility.Molecular plant pathology · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xanthomonas campestris pv. campestris (Xcc) controls virulence and plant infection mechanisms via the activity of the sensor kinase and response regulator pair HpaS/hypersensitive response and pathogenicity G (HrpG). Detailed analysis of the regulatory role of HpaS has suggested the occurrence of further regulators besides HrpG. Here we used in vitro and in vivo approaches to identify the orphan response regulator VemR as another partner of HpaS and to characterize relevant interactions between components of this signalling system. Bacterial two-hybrid and protein pull-down assays revealed that HpaS physically interacts with VemR. Phos-tag SDS-PAGE analysis showed that mutation in hpaS reduced markedly the phosphorylation of VemR in vivo. Mutation analysis reveals that HpaS and VemR contribute to the regulation of motility and this relationship appears to be epistatic. Additionally, we show that VemR control of Xcc motility is due in part to its ability to interact and bind to the flagellum rotor protein FliM. Taken together, the findings describe the unrecognized regulatory role of sensor kinase HpaS and orphan response regulator VemR in the control of motility in Xcc and contribute to the understanding of the complex regulatory mechanisms used by Xcc during plant infection.
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