ArticleEMBO reports2020
CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling.
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Article in EMBO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Gene variants associated with pediatric-onset erythromelalgia: Mendelian and rare-variant association analyses.Pain reports · 2026Article
- Targeting CRMP2 for Chronic Pain: From Molecular Mechanisms to Therapeutic Strategies.Biomedicines · 2026Review
- Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders.Molecular psychiatry · 2026Article
- Neuronal guidance signaling in neurodegenerative diseases: Key regulators that function at neuron-glia and neuroimmune interfaces.Neural regeneration research · 2026Article
- Effects of maternal autoantibody exposure at the cellular level: implications for the developing brain.Frontiers in psychiatry · 2026Review
- Trio and CRMP2 regulate axon branching and Semaphorin3A signaling.Communications biology · 2025Article
- Progress in Molecular Mechanisms of Depression Induced by Mother-Infant Separation and Intervention of Traditional Chinese Medicine.Alpha psychiatry · 2025Review
- Polyglutamylation of microtubules drives neuronal remodeling.Nature communications · 2025Article
- Recent progress in dendritic pruning ofOpen biology · 2024Review
- The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy.Frontiers in cellular neuroscience · 2024Review
- Transcriptomic Analysis of Gene Expression and Effect of Electromagnetic Field in Brain Tissue after Traumatic Brain Injury.Journal of biotechnology and biomedicine · 2024Article
- Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analyses.Channels (Austin, Tex.) · 2023Article
- DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders.Molecular psychiatry · 2023Article
- Target-selective vertebrate motor axon regeneration depends on interaction with glial cells at a peripheral nerve plexus.PLoS biology · 2023Article
- A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration.bioRxiv : the preprint server for biology · 2023Article
- Contribution of the dihydropyrimidinase-like proteins family in synaptic physiology and in neurodevelopmental disorders.Frontiers in neuroscience · 2023Review
- Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy.Molecular neurobiology · 2022Article
- Identification of Anti-Collapsin Response Mediator Protein 2 Antibodies in Patients With Encephalitis or Encephalomyelitis.Frontiers in immunology · 2022Article
- A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.The EMBO journal · 2021Article
- Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling.Molecular neurobiology · 2021Article
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Authors and funding
18 authors at 6 institutions in 3 countries.
Jakub ZiakDepartment of Molecular Neurobiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Romana Weissova *Department of Molecular Neurobiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Kateřina Jeřábková *Department of Transgenic Models of Diseases and Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Martina JanikovaDepartment of Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Roy MaimonDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Tomas PetrasekDepartment of Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Barbora PukajovaDepartment of Molecular Neurobiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Marie KleisnerovaDepartment of Molecular Neurobiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Mengzhe WangInstitute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
Monika S BrillInstitute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
Petr KasparekDepartment of Transgenic Models of Diseases and Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Xunlei ZhouInstitute of Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
Gonzalo Alvarez-BoladoInstitute of Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
Radislav SedlacekDepartment of Transgenic Models of Diseases and Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Thomas MisgeldInstitute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.ORCID 0000-0001-9875-6794
Ales StuchlikDepartment of Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Eran PerlsonDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Martin BalastikDepartment of Molecular Neurobiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.ORCID 0000-0001-5833-9996
Czech Academy of Sciences · CZCzech Academy of Sciences, Institute of Molecular Genetics · CZHeidelberg University · DETechnical University of Munich · DETel Aviv University · ILGerman Center for Neurodegenerative Diseases · DE
Funding
Agentura Pro Zdravotnický Výzkum České Republiky (Czech Health Research Council) 17-30833AAgentura Pro Zdravotnický Výzkum České Republiky (Czech Health Research Council) NV18-04-00085Akademie Věd České Republiky (Akademie věd ČR) RVO 68378050DFG, Collaborative Research Center CRC870-A11DFG, Munich Cluster for Systems Neurology (SyNergy), DFG EXC2145EC | FP7 | FP7 Ideas: European Research Council (FP7 Ideas) 616791EC | FP7 | FP7 Ideas: European Research Council (FP7 Ideas) FP/2007-2013German-Israeli Foundation for Scientific Research and Development (GIF) SFB 870Grantová Agentura České Republiky (GACR) 16-15915SGrantová Agentura České Republiky (GACR) 19-03016SGrantová Agentura, Univerzita Karlova (GA UK) 1062216Grantová Agentura, Univerzita Karlova (GA UK) 524218Grantová Agentura, Univerzita Karlova (GA UK) 682217Ministerstvo Školství, Mládeže a Tělovýchovy (MEYS) CZ.1.05/1.1.00/02.0109Ministerstvo Školství, Mládeže a Tělovýchovy (MEYS) CZ.1.05/2.1.00/19.0395Ministerstvo Školství, Mládeže a Tělovýchovy (MEYS) CZ.2.16/3.1.00/21547Ministerstvo Školství, Mládeže a Tělovýchovy (MEYS) LM2015040Ministerstvo Školství, Mládeže a Tělovýchovy (MEYS) LM2015062Ministerstvo Školství, Mládeže a Tělovýchovy (MEYS) LO1419
Abstract
Regulation of axon guidance and pruning of inappropriate synapses by class 3 semaphorins are key to the development of neural circuits. Collapsin response mediator protein 2 (CRMP2) has been shown to regulate axon guidance by mediating semaphorin 3A (Sema3A) signaling; however, nothing is known about its role in synapse pruning. Here, using newly generated crmp2
Indexed as
Autism Spectrum DisorderSemaphorinsAnimalsDendritic SpinesIntercellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, KnockoutNerve Tissue ProteinsNeuronal PlasticityNeuronsSignal Transductioncollapsin response mediator protein-2Intercellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsSema3f protein, mouseSemaphorinsaxon guidancecollapsin response mediator protein 2dendritic spinessemaphorinssynapse pruning
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.