ArticleNeurogastroenterology and motility2020
The rhythm and rate of distension-induced esophageal contractility: A physiomarker of esophageal function.
Article in Neurogastroenterology and motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Retrograde cricopharyngeus dysfunction (R-CPD), also known as inability to belch syndrome-a narrative review.Translational gastroenterology and hepatology · 2026Review
- Modeling based insights into mechanical dysfunction in esophageal motility disorders.PLoS computational biology · 2025Article
- Functional Lumen Imaging Probe Panometry.Gastrointestinal endoscopy clinics of North America · 2025Review
- A Standardized Approach to Performing and Interpreting Functional Lumen Imaging Probe Panometry for Esophageal Motility Disorders: The Dallas Consensus.Gastroenterology · 2025Article
- Direct and Retrograde Wave Propagation in Unidirectionally Coupled Wilson-Cowan Oscillators.Physical review letters · 2025Article
- Repetitive antegrade contractions on high-resolution manometry: A physiologic pattern related to sustained esophageal distention in Abelchia.Neurogastroenterology and motility · 2025Article
- Age Affects Esophageal Secondary Peristalsis More Than Primary as Assessed by FLIP Panometry and High-resolution Manometry.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Intestinal organ chips for disease modelling and personalized medicine.Nature reviews. Gastroenterology & hepatology · 2024Review
- Enhancing Chicago Classification diagnoses with functional lumen imaging probe-mechanics (FLIP-MECH).Neurogastroenterology and motility · 2024Article
- Endoscopic impedance planimetry versus high-resolution manometry (HRM) for pre-operative motility evaluation in anti-reflux surgery.Surgical endoscopy · 2024Article
- The Use of Intraoperative Esophageal Functional Luminal Imaging Probe for Prediction of Therapeutic Outcomes in Achalasia Patients.Journal of neurogastroenterology and motility · 2023Article
- Advances in the Diagnosis and Management of Achalasia and Achalasia-Like Syndromes: Insights From HRM and FLIP.Gastro hep advances · 2023Article
- Validation of Clinically Relevant Thresholds of Esophagogastric Junction Obstruction Using FLIP Panometry.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Validation of secondary peristalsis classification using FLIP panometry in 741 subjects undergoing manometry.Neurogastroenterology and motility · 2022Article
- Dysphagia: Novel and Emerging Diagnostic Modalities.Gastroenterology clinics of North America · 2021Review
- Evaluating esophageal motility beyond primary peristalsis: Assessing esophagogastric junction opening mechanics and secondary peristalsis in patients with normal manometry.Neurogastroenterology and motility · 2021Article
- Estimation of mechanical work done to open the esophagogastric junction using functional lumen imaging probe panometry.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Esophagogastric Junction Opening Parameters Are Consistently Abnormal in Untreated Achalasia.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- Achalasia subtypes can be identified with functional luminal imaging probe (FLIP) panometry using a supervised machine learning process.Neurogastroenterology and motility · 2021Article
- Normal Functional Luminal Imaging Probe Panometry Findings Associate With Lack of Major Esophageal Motility Disorder on High-Resolution Manometry.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDistention of the esophagus elicits a unique pattern of repetitive contractions in healthy controls. We aimed to assess the rhythm and rate of distension-induced contractile patterns between achalasia and controls and identify factors that distinguish the normal contractile response to distension.
methodsTwenty asymptomatic controls and 140 adult patients with treatment-naïve achalasia defined by HRM (29 type I, 81 type II, 30 type III) were prospectively evaluated with functional luminal imaging probe (FLIP) during sedated endoscopy. 16-cm FLIP balloons were positioned within the distal esophagus during stepwise balloon distension. Functional luminal imaging probe panometry studies were retrospectively analyzed using a customized program. KEY
resultsAll controls had contractility in a repetitive antegrade contraction (RAC) pattern with a rate of mean (10-90th) 6 (4-8) contractions per minute. 19/20 controls had > 6 consecutive antegrade contractions (ACs), that is, duration > 6 ACs, >6 cm in length, at a rate of 6 ± 3 contractions per minute (met the "Rule-of-6s"). 50 achalasia patients had repetitive contractions that occurred at a rates of 11 (7 - 15) ACs per minute; P < .001 compared with controls, or 12 (8-15) repetitive retrograde contractions per minute. Only 1/140 achalasia patients had a contractile response that met the "Rule-of-6s."
conclusionThe normal contractile response to sustained distention is associated with > 6 RACs with a consistent rate of 6 ± 3 per minute, which was exceptionally rare in achalasia. These findings support that the RAC pattern is disrupted in achalasia and the faster rate may be a manifestation of abnormal inhibition and/or a reduced refractory period.
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