Evidence map›Paper›PMID 31919880›Full record

ArticleAmerican journal of hematology2020

Haptoglobin genotype predicts severe acute vaso-occlusive pain episodes in children with sickle cell anemia.

Shaina M Willen, Joel Brennan McNeil, Mark Rodeghier, Vern Eric Kerchberger, Ciara M Shaver, Julie A Bastarache, Martin H Steinberg, Michael R DeBaun, Lorraine B Ware

Abstract readLetterMulticenter Study
In one paragraph

Article in American journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shaina M WillenDivision of Pulmonary Medicine, Department of Pediatrics, UCSF Benioff Children's Hospital San Francisco, San Francisco, California.ORCID 0000-0002-6691-816X
Joel Brennan McNeilDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-9200-1881
Mark RodeghierRodeghier Consultants, Chicago, Illinois.
Vern Eric KerchbergerDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Ciara M ShaverDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Julie A BastaracheDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Martin H SteinbergDivision of Hematology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.ORCID 0000-0001-8800-8020
Michael R DeBaunDivision of Hematology/Oncology, Department of Pediatrics, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-0574-1604
Lorraine B WareDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

Funding

Asthma and Nocturnal Hypoxemia in Sickle Cell Anemia IIR01HL079937 · NHLBI · WASHINGTON UNIVERSITY · PI DEBAUN, MICHAEL R., STRUNK, ROBERT · 2005 to 2013
$10.4M
Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
Genetic Modulation of Sickle Cell DiseaseR01HL068970 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2001 to 2010
$7.0M
Genome-Wide Association Studies in Sickle Cell Anemia and in CentenariansR01HL087681 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2007 to 2010
$6.0M
Genetic Diversity of Sickle Cell AnemiaRC2HL101212 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2009 to 2010
$3.0M
Targeting cell-free hemoglobin in sepsis to reduce lung microvascular permeability: mechanistic and translational studiesR01HL135849 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, JULIE ANNE, WARE, LORRAINE B · 2017 to 2020
$2.2M
Midcareer Investigator Award in Patient-Oriented Research in Acute Lung InjuryK24HL103836 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2010 to 2020
$1.6M
Mechanisms of airspace inflammation caused by cell-free hemoglobin during ARDSK08HL136888 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHAVER, CIARA M · 2017 to 2021
$858k
NHLBI NIH HHS K08 HL136888NHLBI NIH HHS K24 HL103836NHLBI NIH HHS R01 HL068970NHLBI NIH HHS R01 HL079937NHLBI NIH HHS R01 HL087681NHLBI NIH HHS R01 HL135849NHLBI NIH HHS RC2 HL101212NHLBI NIH HHS T32 HL087738
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic Association StudiesAcute Chest SyndromeAcute PainAdolescentAllelesAnemia, Sickle CellArterial Occlusive DiseasesChildChild, PreschoolGene FrequencyGenetic Predisposition to DiseaseHaptoglobinsHemeHumansIncidenceProspective StudiesHaptoglobinsHemeHP protein, human

Identifiers

PMID31919880
PMCPMC7343605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.