Evidence map›Paper›PMID 31919777›Full record

ArticleMolecular neurobiology2020

Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny.

Nirav J Patel, Kirk J Hogan, Elias Rizk, Krista Stewart, Andy Madrid, Sivan Vadakkadath Meethal, Reid Alisch, Laura Borth, Ligia A Papale, Solomon Ondoma and 10 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. The Role of Methylation Modification in Neural Injury and Repair.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits.Oxidative medicine and cellular longevity · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Nirav J PatelDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Kirk J HoganDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Elias RizkDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Krista StewartDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Andy MadridDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Sivan Vadakkadath MeethalDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Reid AlischDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Laura BorthDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Ligia A PapaleDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Solomon OndomaDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Logan R GorgesDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Kara WeberDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Wendell LakeDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Andrew BauerDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Nithya HariharanDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Thomas KuehnDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA.
Thomas CookDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA.
Sunduz KelesDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA.
Michael A NewtonDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA.
Bermans J IskandarDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Avenue, K4/832, Madison, WI, 53792, USA. Iskandar@neurosurgery.wisc.edu.ORCID http://orcid.org/0000-0002-3856-1597
University of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
TrainingU54AI117924 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CRAVEN, MARK W. · 2014 to 2018
$11.3M
Folic Acid Enhances Repair Mechanism in the Adult CNSR01HD047516 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ISKANDAR, BERMANS J · 2006 to 2010
$964k
HSRD VA IIR 14-435March of Dimes Gene Discovery and Translational Research Grant #6-FY14-435NCATS NIH HHS UL1 TR002373NCATS NIH HHS UL1TR002373NIAID NIH HHS U54 AI117924NICHD NIH HHS R01 HD047516NIH NIAID U54AI117924NIH NICHD 1R01HD047516NIH NICHD 3R01HD047516-04S1UW Department of Neurological Surgery R & D None
6 · The paper itself

Abstract

Folate supplementation in F0 mating rodents increases regeneration of injured spinal axons in vivo in 4 or more generations of progeny (F1-F4) in the absence of interval folate administration to the progeny. Transmission of the enhanced regeneration phenotype to untreated progeny parallels axonal growth in neuron culture after in vivo folate administration to the F0 ancestors alone, in correlation with differential patterns of genomic DNA methylation and RNA transcription in treated lineages. Enhanced axonal regeneration phenotypes are observed with diverse folate preparations and routes of administration, in outbred and inbred rodent strains, and in two rodent genera comprising rats and mice, and are reversed in F4-F5 progeny by pretreatment with DNA demethylating agents prior to phenotyping. Uniform transmission of the enhanced regeneration phenotype to progeny together with differential patterns of DNA methylation and RNA expression is consistent with a non-Mendelian mechanism. The capacity of an essential nutritional co-factor to induce a beneficial transgenerational phenotype in untreated offspring carries broad implications for the diagnosis, prevention, and treatment of inborn and acquired disorders.

Indexed as

Administration, OralAnimalsAxonsAzacitidineDNA MethylationFemaleFolic AcidGenomeHistone Deacetylase InhibitorsHydroxamic AcidsInjections, IntraperitonealMaleNerve RegenerationNeuronsPhenotypeRats, Sprague-DawleyAzacitidineFolic AcidHistone Deacetylase InhibitorsHydroxamic Acidstrichostatin AAxonal regenerationCentral nervous system (CNS)DNA methylationEpigeneticsFolic acidSpinal cord injuryTransgenerational inheritance

Identifiers

PMID31919777
PMCPMC7125003
OpenAlexW2999127553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.