Evidence map›Paper›PMID 31919767›Full record

ArticlePflugers Archiv : European journal of physiology2020

Characterization and functional roles of KCNQ-encoded voltage-gated potassium (Kv7) channels in human corpus cavernosum smooth muscle.

Jun Ho Lee, Mee Ree Chae, Su Jeong Kang, Hyun Hwan Sung, Deok Hyun Han, Insuk So, Jong Kwan Park, Sung Won Lee

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Chemical modulation of Kv7 potassium channels.RSC medicinal chemistry · 2021
    Review
  3. Kv7 Channels and Excitability Disorders.Handbook of experimental pharmacology · 2021
    Article
  4. The agonistic action of URO-K10 on Kv7.4 and 7.5 channels is attenuated by co-expression of KCNE4 ancillary subunit.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Jun Ho LeeDepartment of Urology, National Police Hospital, Seoul, South Korea.
Mee Ree ChaeDepartment of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
Su Jeong KangDepartment of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
Hyun Hwan SungDepartment of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
Deok Hyun HanDepartment of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
Insuk SoDepartment of Physiology and Biophysics, Seoul National University College of Medicine, Seoul, South Korea.
Jong Kwan ParkDepartment of Urology, Medical School, and Institute for Medical Sciences, Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University Hospital, Chonbuk National University, Jeonju, South Korea.
Sung Won LeeDepartment of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. drswlee@skku.edu.
Sungkyunkwan University · KRSamsung Medical Center · KRJeonbuk National University Hospital · KRNational Police Hospital · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The group of KCNQ-encoded voltage-gated potassium (Kv7) channels includes five family members (Kv7.1-7.5). We examined the molecular expression and functional roles of Kv7 channels in corporal smooth muscle (CSM). Isolated rabbit CSM strips were mounted in an organ bath system to characterize Kv7 channels during CSM relaxation. Intracellular Ca

Indexed as

Muscle RelaxationAnilidesAnimalsAnthracenesBridged Bicyclo CompoundsCells, CulturedCyclic AMP-Dependent Protein KinasesDiabetes Mellitus, ExperimentalHumansHydrazonesIsoquinolinesIsoxazolesMaleMuscle ContractionMuscle, SmoothMyocytes, Smooth Muscle10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrileAnilidesAnthracenesBridged Bicyclo CompoundsCyclic AMP-Dependent Protein KinasesHydrazonesIsoquinolinesIsoxazolesN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-mesitybicyclo(2.2.1)heptane-2-carboxamidePotassium Channel BlockersPotassium Channels, Voltage-GatedProtein Kinase InhibitorsSulfonamidesCorpus cavernosumErectile dysfunctionKCNEKCNQKv7.4 channel

Identifiers

PMID31919767
OpenAlexW3000647289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.