SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2020
Large-for-Size Orthotopic Liver Transplantation: a Systematic Review of Definitions, Outcomes, and Solutions.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Ex-vivo right posterior sectionectomy for large-for-size mismatch in pediatric liver transplant recipients.Langenbeck's archives of surgery · 2026Article
- Risk factors for inferior right hepatic vein occlusion following right lobe living donor liver transplantation: a single-center experience with 240 cases.Updates in surgery · 2026Article
- Ex situ right posterior sectionectomy (H6,7) as liver graft reduction to overcome mismatch for small-body size adult.Updates in surgery · 2025Article
- Improved graft survival by using three-dimensional printing of intra-abdominal cavity to prevent large-for-size syndrome in liver transplantation.Annals of hepato-biliary-pancreatic surgery · 2025Article
- Systematic Sex-Based Inequity in the MELD Score-Based Allocation System for Liver Transplantation in Germany.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Article
- Comment on Portal Hemodynamics in Liver Transplantation: Do not Shunt The Large-For-Flow!Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Impact of sex on the outcomes of deceased donor liver transplantation.World journal of transplantation · 2024Article
- Maximizing utility of nondirected living liver donor grafts using machine learning.Frontiers in immunology · 2023Article
- Understanding Local Hemodynamic Changes After Liver Transplant: Different Entities or Simply Different Sides to the Same Coin?Transplantation direct · 2022Review
- Pluripotent Stem Cell-derived Strategies to Treat Acute Liver Failure: Current Status and Future Directions.Journal of clinical and translational hepatology · 2022Review
- Adopting Individualized Strategies to Prevent Large-For-Size Syndrome in Adult Liver Transplant Recipients: The Graft Morphology Should Also Be Taken Into Account.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- 3D Printing Model of Abdominal Cavity of Liver Transplantation Recipient to Prevent Large-for-Size Syndrome.International journal of bioprinting · 2022Article
- Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis.Frontiers in surgery · 2022Article
- Predicting the available space for liver transplantation in cirrhotic patients: a computed tomography-based volumetric study.Hepatology international · 2021Article
- Long-Term Outcomes of Abdominal Wall Reconstruction with Expanded Polytetrafluoroethylene Mesh in Pediatric Liver Transplantation.Journal of clinical medicine · 2021Article
- A Novel Strategy for Preventing Posttransplant Large-For-Size Syndrome in Adult Liver Transplant Recipients: A Pilot Study.Transplant international : official journal of the European Society for Organ TransplantationArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe systematically reviewed the literature on definitions and outcomes of large-for-size (LFS) syndrome in orthotopic liver transplantation (LT).
methodsThis systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Cochrane Library, PubMed, and Embase were searched (January 1990-January 2019) for studies reporting LFS in LT. Primary outcomes were definitions and mortality of LFS LT.
resultsEleven studies reporting patients with LFS LT were identified. Four different formulas (graft-to-recipient weight ratio (GRWR), body surface area index (BSAi), donor standardized total liver volume (sTLV)-to-recipient sTLV ratio, and graft weight/right anteroposterior distance (RAP) ratio) with their critical thresholds were found. There were 81 patients (54% women) with a median weight and height of 62.5 kg (range, 40-105 kg) and 165 cm (range, 145-180 cm). The median graft weight was 1772 g (range, 1290-2400 g), and the median GWRW was 2.77% (range, 2.1-4.00%). Graft venous outflow obstruction was described in seven patients (8.6%). At the time of LT, fascial closure was not achieved in 24 patients (29.6%) and the graft size was reduced by a liver resection in three patients (3.7%). Thirteen deaths (16%) were reported in the first 90 postoperative days with two patients undergoing re-transplant.
conclusionsLFS LT remains heterogeneously defined but characterized by high mortality rates despite the use of tailored surgical solutions (graft reduction and open abdomen). A composite definition is proposed in order to better describe LFS clinical syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.