ArticleEuropean journal of nuclear medicine and molecular imaging2020
Superior performance of 18F-fluorocholine digital PET/CT in the detection of parathyroid adenomas.
Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04570033 (The Utility of 18F-fluorocholine PET/CT in the Imaging of Parathyroid Adenomas), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Utility of 18F-fluorocholine PET/CT in the Imaging of Parathyroid Adenomas
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Assessment and Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Pooled it
- Slice Level Classification of Parathyroid Adenoma Using Arterial Phase CT Images with Hybrid Light Attention Mechanism Based Residual Framework.Bioengineering (Basel, Switzerland) · 2026Article
- Injection method alters diagnostic confidence and quantitative metrics in [EJNMMI reports · 2026Article
- Digital versus analogue PET in parathyroid imaging: comparison of PET metrics and machine learning-based characterisation of hyperfunctioning lesions (the DIGI-PET study).European journal of nuclear medicine and molecular imaging · 2026Article
- Surgical management of intrathyroidal parathyroid adenoma with nodular goiter: a case report highlighting SPECT/CT localization.Gland surgery · 2025Article
- Time to shift to Digital PET/CT?Nuclear medicine and molecular imaging · 2025Article
- Comparison of digital and analog [Scientific reports · 2024Article
- Preoperative identification of small parathyroid adenomas-better done by fluorocholine positron emission tomography/computed tomography.Gland surgery · 2023Article
- Giant functional parathyroid carcinoma: a case report and literature review.Frontiers in oncology · 2023Article
- Shining Damaged Hearts: Immunotherapy-Related Cardiotoxicity in the Spotlight of Nuclear Cardiology.International journal of molecular sciences · 2022Review
- Article
- Performance of quantitative measurements in [Frontiers in medicine · 2022Article
- Silicon-photomultiplier-based PET/CT reduces the minimum detectable activity of iodine-124.Scientific reports · 2021Article
- The EANM practice guidelines for parathyroid imaging.European journal of nuclear medicine and molecular imaging · 2021Article
- WillEndocrine · 2021Review
- A rare cause of persistent hyperparathyroidism.Clinical case reports · 2021Article
- Article
- Comparison of Neck Ultrasonography, Dual PhaseIndian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare detectability of hyperfunctioning parathyroid tissue (HPT) by digital and analog 18F-fluorocholine PET/CT in patients with primary hyperparathyroidism and negative/inconclusive 99mTc-MIBI scintigraphy-SPECT/CT. MATERIALS AND
methodsThirty-three patients with primary hyperparathyroidism and negative/inconclusive 99mTc-MIBI scintigraphy-SPECT/CT were prospectively included. All patients accepted to be scanned by digital and analog PET/CT in the same imaging session after a single injection of 18F-fluorocholine. Three nuclear medicine physicians evaluated the digital and analog PET/CT datasets to assess the detection rate of HPT. Maximum standard uptake values (SUVmax) of HPT and locoregional lymph nodes were measured in both systems.
resultsHPT was detected in 30/33 patients by the digital system, whereas it was detected in 22/33 patients by the analog system (p < 0.01). Moreover, in 21 of these 33 patients, both systems detected one focal 18F-fluorocholine uptake, and in one patient the digital system detected two foci. Histopathology demonstrated HPT in 32 patients and it was inconclusive in one patient. The digital PET/CT detected HPT in 29 of the 32 patients, and the analog system in 22 of the 32 (p < 0.01). All HPT suspected lesions resected and detected only by the digital system (n = 8) were < 10 mm (7.5 ± 1.3 mm), while those detected by both systems (n = 22) were > 10 mm (13 ± 3.8 mm). SUVmax of HPT lesions was significantly higher than SUVmax of locoregional lymph node independently of the PET/CT system used (4.5 ± 1.9 vs. 2.9 ± 1.3, p < 0.0001).
conclusionsDigital PET/CT offers superior performance over analog system in patients with suspected HPT and previous negative/inconclusive imaging examinations, particularly in sub-centimeter lesions. SUVmax can help in the differentiation between HTP and locoregional lymph nodes.
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