Evidence map›Paper›PMID 31919571›Full record

ArticleCellular and molecular life sciences : CMLS2020

Biased agonists at the human Y

Anette Kaiser, Lizzy Wanka, Isabelle Ziffert, Annette G Beck-Sickinger

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Intranasal Application of Peptides Modulating the Neuropeptide Y System.ACS pharmacology & translational science · 2025
    Article
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anette Kaiser *Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstr. 34, 04103, Leipzig, Germany.
Lizzy Wanka *Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstr. 34, 04103, Leipzig, Germany.
Isabelle ZiffertInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstr. 34, 04103, Leipzig, Germany.
Annette G Beck-SickingerInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstr. 34, 04103, Leipzig, Germany. abeck-sickinger@uni-leipzig.de.ORCID http://orcid.org/0000-0003-4560-8020
Leipzig University · DELeipzig University of Applied Sciences · DE

Funding

Deutsche Forschungsgemeinschaft SFB 1052/A3Deutsche Forschungsgemeinschaft SFB 1423/B1Deutsche Forschungsgemeinschaft SFB 1423/B3
6 · The paper itself

Abstract

Functionally selective ligands to address specific cellular responses downstream of G protein-coupled receptors (GPCR) open up new possibilities for therapeutics. We designed and characterized novel subtype- and pathway-selective ligands. Substitution of position Q

Indexed as

AnimalsArrestinsCattleCell LineCell MembraneCyclic AMPGTP-Binding ProteinsHEK293 CellsHumansLigandsNeuropeptide YProlineProtein BindingReceptors, G-Protein-CoupledSignal Transductionarrestin3ArrestinsCyclic AMPGTP-Binding ProteinsLigandsNeuropeptide YProlineReceptors, G-Protein-CoupledArrestinGPCRG ProteinNPYSignaling bias

Identifiers

PMID31919571
PMCPMC11104783
OpenAlexW3000136433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.