ArticleJournal of neurology2020
Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia.
Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Sense of agency and its disturbances: A systematic review targeting the intentional binding effect in neuropsychiatric disorders.Psychiatry and clinical neurosciences · 2024Pooled it
- Unraveling the mystery of alien hand syndrome: when your hand has a mind of its own.Orphanet journal of rare diseases · 2025Review
- Alien Hand: Current Research Trends.Current neurology and neuroscience reports · 2025Review
- The Paper-Toss Test: enhancing bedside recognition of corticobasal syndrome.Frontiers in neurology · 2025Article
- Apraxia phenotypes and frontotemporal lobar degeneration.Journal of neurology · 2024Article
- Apraxia: From Neuroanatomical Pathways to Clinical Manifestations.Current neurology and neuroscience reports · 2024Review
- Alien hand syndrome: Pathophysiology, semiology and differential diagnosis with psychiatric disorders (Review).Biomedical reports · 2024Review
- The enigma of depression in corticobasal degeneration, a frequent but poorly understood co-morbidity.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Pathomechanisms of cognitive and behavioral impairment in corticobasal degeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Clinical Spectrum of Tauopathies.Frontiers in neurology · 2022Review
- Corticobasal Syndrome, Optic Ataxia and Exaggerated Startle Response: An Atypical Presentation of Creutzfeldt-Jakob Disease.Movement disorders clinical practice · 2021Article
- Case Report: Good Prognosis of Mixed Alien Hand Syndrome by Verbal-Cue Rehabilitation Exercise.Frontiers in neurology · 2021Article
- A Critical Review of Alien Limb-Related Phenomena and Implications for Functional Magnetic Resonance Imaging Studies.Frontiers in neurology · 2021Review
- Alien limb syndrome: A Bayesian account of unwanted actions.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Review
- PET Tau Imaging and Motor Impairments Differ Between Corticobasal Syndrome and Progressive Supranuclear Palsy With and Without Alzheimer's Disease Biomarkers.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Alien limb refers to movements that seem purposeful but are independent of patients' reported intentions. Alien limb often co-occurs with apraxia in the corticobasal syndrome, and anatomical and phenomenological comparisons have led to the suggestion that alien limb and apraxia may be causally related as failures of goal-directed movements. Here, we characterised the nature of alien limb symptoms in patients with the corticobasal syndrome (n = 30) and their relationship to limb apraxia. Twenty-five patients with progressive supranuclear palsy Richardson syndrome served as a disease control group. Structured examinations of praxis, motor function, cognition and alien limb were undertaken in patients attending a regional specialist clinic. Twenty-eight patients with corticobasal syndrome (93%) demonstrated significant apraxia and this was often asymmetrical, with the left hand preferentially affected in 23/30 (77%) patients. Moreover, 25/30 (83%) patients reported one or more symptoms consistent with alien limb. The range of these phenomena was broad, including changes in the sense of ownership and control as well as unwanted movements. Regression analyses showed no significant association between the severity of limb apraxia and either the occurrence of an alien limb or the number of alien limb phenomena reported. Bayesian estimation showed a low probability for a positive association between alien limb and apraxia, suggesting that alien limb phenomena are not likely to be related to severity apraxia. Our results shed light on the phenomenology of these disabling and as yet untreatable clinical features, with relevance to theoretical models of voluntary action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.