Evidence map›Paper›PMID 31919563›Full record

ArticlePsychopharmacology2020

Cannabidiol-induced panicolytic-like effects and fear-induced antinociception impairment: the role of the CB

Asmat Ullah Khan, Luiz Luciano Falconi-Sobrinho, Tayllon Dos Anjos-Garcia, Maria de Fátima Dos Santos Sampaio, José Alexandre de Souza Crippa, Leda Menescal-de-Oliveira, Norberto Cysne Coimbra

Abstract read
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In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Asmat Ullah KhanLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Luiz Luciano Falconi-SobrinhoLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Tayllon Dos Anjos-GarciaLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Maria de Fátima Dos Santos SampaioLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
José Alexandre de Souza CrippaDepartment of Neuroscience and Behavioural Sciences, Division of Psychiatry, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Leda Menescal-de-OliveiraNeurobiology of Emotions (NAP-USP-NuPNE) Research Centre, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Norberto Cysne CoimbraLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. nccoimbr@fmrp.usp.br.ORCID http://orcid.org/0000-0002-4676-2620
Universidade de São Paulo · BRUniversidade de Ribeirão Preto · BRUniversity of Azad Jammu and Kashmir · PK

Funding

CNpq 427397/2018-9FAPESP 2017/11855-8
6 · The paper itself

Abstract

rationaleThe behavioural effects elicited by chemical constituents of Cannabis sativa, such as cannabidiol (CBD), on the ventromedial hypothalamus (VMH) are not well understood. There is evidence that VMH neurons play a relevant role in the modulation of unconditioned fear-related defensive behavioural reactions displayed by laboratory animals.

objectivesThis study was designed to explore the specific pattern of distribution of the CB

methodsA panic attack-like state was triggered in Wistar rats by intra-VMH microinjections of N-methyl-D-aspartate (NMDA). One of three different doses of CBD was microinjected into the VMH prior to local administration of NMDA. In addition, the most effective dose of CBD was used after pre-treatment with the CB

resultsThe morphological procedures demonstrated distribution of labelled CB

conclusionThese findings suggest that CBD causes panicolytic-like effects and reduces unconditioned fear-induced antinociception when administered in the VMH, and these effects are mediated by the CB

Indexed as

AnimalsCannabidiolFearInjections, IntraventricularMaleN-MethylaspartatePain MeasurementPanic DisorderPiperidinesPyrazolesRatsRats, WistarReceptor, Cannabinoid, CB1Ventromedial Hypothalamic NucleusAM 251CannabidiolN-MethylaspartatePiperidinesPyrazolesReceptor, Cannabinoid, CB1CannabidiolCB1 receptorEndocannabinoid systemPanic attack-like behaviourUnconditioned fear-induced antinociceptionVentromedial hypothalamus

Identifiers

PMID31919563
OpenAlexW2999962438

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.