Evidence map›Paper›PMID 31919418›Full record

SynthesisNature communications2020

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.

Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K Hedman, Jemma B Wilk, Michael P Morley, Mark D Chaffin and 137 more

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07355088 (Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators), which is not on this map. Cited by 508 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
508citing papers in PubMed, 14 pooled it
97.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07355088 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study

Typeobservational_patient_registrySponsorXinjiang Medical UniversityRan2026 to 2028Enrolled600ConditionsChronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
3 · Its place in the literature

Who cites it

508 citing papers in PubMed, 14 syntheses or guidelines pooled it, 909 citations in OpenAlex.

  1. Pooled it
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  3. The genetics of cannabis lifetime use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  17. Multi-Omics Genome-Wide to Explore the Formation and Development Targets for Intracranial Aneurysms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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448 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

147 authors at 20 institutions in 12 countries.

Sonia ShahInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0001-5860-4526
Albert HenryInstitute of Cardiovascular Science, University College London, London, UK.ORCID http://orcid.org/0000-0001-7422-2288
Carolina RoselliProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5267-6756
Honghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3043-3942
Garðar SveinbjörnssondeCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.
Ghazaleh FatemifarBritish Heart Foundation Research Accelerator, University College London, London, UK.
Åsa K HedmanCardiovascular Medicine unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
Jemma B WilkPfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA.
Michael P MorleyPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mark D ChaffinProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1234-5562
Anna HelgadottirdeCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-1806-2467
Niek VerweijProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4303-7685
Abbas DehghanDepartment of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Peter AlmgrenDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-0473-0241
Charlotte AnderssonNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Krishna G AragamProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Johan ÄrnlövDepartment of Neurobiology, Care Sciences and Society/ Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
Joshua D BackmanRegeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Mary L BiggsDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Heather L BloomDivision of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA.
Jeffrey BrandimartoPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael R BrownDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA.
Leonard BuckbinderPfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA.
David J CareyDepartment of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Xing ChenPfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA.
Xu ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7299-3238
Jonathan ChungRegeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
William ChutkowNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Graciela E DelgadoVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
Spiros DenaxasBritish Heart Foundation Research Accelerator, University College London, London, UK.
Alexander S DoneyDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Samuel C DudleyCardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Michael E DunnRegeneron Pharmaceuticals, Cardiovascular Research, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Gunnar EngströmDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Tõnu EskoProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Stephan B FelixDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Chris FinanInstitute of Cardiovascular Science, University College London, London, UK.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9476-7143
Sahar GhasemiDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, 75185, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
John S GottdienerDepartment of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Stefan GrossDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-4121-7161
Daníel F GuðbjartssondeCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Rebecca GutmannDivision of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Christopher M HaggertyDepartment of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Craig L HydePfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6939-287X
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-2256-6972
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Maryam KavousiDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0QQ, UK.
Marcus E KleberVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0663-7275
Lars KøberDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Andrea KoekemoerDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.ORCID http://orcid.org/0000-0001-8222-3547
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0002-5017-7344
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Cecilia M LindgrenProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4903-9374
Barry LondonDivision of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.
Luca A LottaMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Ruth C LoveringInstitute of Cardiovascular Science, University College London, London, UK.ORCID http://orcid.org/0000-0002-9791-0064
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-3137-6337
Patrik MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Kenneth B MarguliesPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Winfried MärzDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Olle MelanderDepartment of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.
Ify R MordiDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.ORCID http://orcid.org/0000-0002-2686-729X
Thomas MorganNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Andrew D MorrisUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.ORCID http://orcid.org/0000-0002-1766-0473
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA.
Michael W NaglePfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4677-7582
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.ORCID http://orcid.org/0000-0001-8025-2897
Alexander NiessnerDepartment of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
Teemu NiiranenNational Institute for Health and Welfare, Helsinki, Finland.
Michelle L O'DonoghueTIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Anjali T OwensPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Colin N A PalmerDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.ORCID http://orcid.org/0000-0002-6415-6560
Helen M ParryDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Markus PerolaNational Institute for Health and Welfare, Helsinki, Finland.
Eliana Portilla-FernandezDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Bruce M PsatyDepartment of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Regeneron Genetics Center
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3071-7278
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Simon P R RomaineDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Perttu SaloNational Institute for Health and Welfare, Helsinki, Finland.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0001-7563-5324
Jessica van SettenDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-4934-7510
Alaa A ShalabyDivision of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA.
Diane T SmelserDepartment of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.
Nicholas L SmithKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
Steen StenderDepartment of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, København, Denmark.
David J StottInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Per SvenssonDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0372-6272
Mari-Liis TammesooEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, LABiomed and Departments of Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID http://orcid.org/0000-0002-2756-4370
Maris Teder-LavingEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.ORCID http://orcid.org/0000-0002-5872-1850
Alexander TeumerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Guðmundur ThorgeirssondeCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.
Christian Torp-PedersenDepartment of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Benoit TylTranslational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, 50 rue Carnot, 92284, Suresnes, France.ORCID http://orcid.org/0000-0001-5297-8412
Andre G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Abirami VeluchamyDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Uwe VölkerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Adriaan A VoorsSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Xiaosong WangNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Dawn WaterworthHuman Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Peter E WeekeDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Raul WeissDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA.
Kerri L WigginsDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2749-1279
Heming XingNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Laura M Yerges-ArmstrongHuman Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Bing YuDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA.
Faiez ZannadUniversité de Lorraine, CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, 54500, Vandoeuvre Lès, Nancy, France.
Jing Hua ZhaoMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Harry HemingwayBritish Heart Foundation Research Accelerator, University College London, London, UK.ORCID http://orcid.org/0000-0003-2279-0624
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
John J V McMurrayBHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Jian YangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0003-2001-2474
Peter M VisscherInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0002-2143-8760
Christopher Newton-ChehProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Anders MalarstigCardiovascular Medicine unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
Hilma HolmdeCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.
Steven A LubitzProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9599-4866
Naveed SattarBHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.ORCID http://orcid.org/0000-0002-1604-2593
Michael V HolmesMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
Thomas P CappolaPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9630-7204
Folkert W AsselbergsInstitute of Cardiovascular Science, University College London, London, UK.ORCID http://orcid.org/0000-0002-1692-8669
Aroon D HingoraniInstitute of Cardiovascular Science, University College London, London, UK.
Karoline KuchenbaeckerDivision of Psychiatry, University College of London, London, W1T 7NF, UK.ORCID http://orcid.org/0000-0001-9726-603X
Patrick T EllinorProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2067-0533
Chim C LangDivision of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Kari StefanssondeCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.
J Gustav SmithProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ramachandran S VasanNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0001-7357-5970
Daniel I SwerdlowInstitute of Cardiovascular Science, University College London, London, UK.
R Thomas LumbersBritish Heart Foundation Research Accelerator, University College London, London, UK. t.lumbers@ucl.ac.uk.ORCID http://orcid.org/0000-0002-9077-4741
Regeneron (United States) · USBroad Institute · USdeCODE Genetics (Iceland) · ISPfizer (United States) · USUniversitätsmedizin Greifswald · DEUniversity of Cambridge · GBUniversity of Dundee · GBUniversity of Pennsylvania · USBrigham and Women's Hospital · USBritish Heart Foundation · GBErasmus MC · NLUniversity of Glasgow · GBUniversity of Leicester · GBBoston University · USCentre for Human Genetics · GBCopenhagen University Hospital · DKFinnish Institute for Health and Welfare · FIGeisinger Medical Center · USKarolinska Institutet · SELund University · SE

Funding

CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
Mentoring in Arrhythmia ResearchK24HL105780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2011 to 2020
$1.2M
British Heart Foundation FS/18/23/33512British Heart Foundation RG/10/12/28456British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946British Heart Foundation SP/13/6/30554Cancer Research UK 14136Chief Scientist Office PCL/17/07Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_PC_13040Medical Research Council MC_PC_13041Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_12015/1Medical Research Council MR/K006584/1Medical Research Council MR/N003284/1Medical Research Council MR/S003754/1NHLBI NIH HHS K24 HL105780NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL139731NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114
6 · The paper itself

Abstract

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.

Indexed as

Adaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsAtrial FibrillationCardiomyopathiesCarrier ProteinsCase-Control StudiesCoronary Artery DiseaseCyclin-Dependent Kinase Inhibitor p21Genome-Wide Association StudyHeart FailureHumansMendelian Randomization AnalysisMicrofilament ProteinsMuscle ProteinsRisk FactorsVentricular Function, LeftAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBAG3 protein, humanCarrier ProteinsCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Microfilament ProteinsMuscle ProteinsMYOZ1 protein, humanSYNPO2L protein, human

Identifiers

PMID31919418
PMCPMC6952380
OpenAlexW2999230481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.