ArticleScientific reports2020
Antioxidant Activities of an Exopolysaccharide (DeinoPol) Produced by the Extreme Radiation-Resistant Bacterium Deinococcus radiodurans.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Not Just an Aroma Compound: Expanding Perspectives on Diacetyl in Food Systems and Human Health.Molecules (Basel, Switzerland) · 2026Review
- Bioactivity of microbial biofilms in extreme environments.Frontiers in microbiology · 2025Review
- Ultraviolet, Did the Cell See It from the Side or the Bottom? Assessment and Modeling of UV Effects on Cultured Cells Using the CL-1000 UV-Crosslinker.Biotech (Basel (Switzerland)) · 2024Article
- Development and Regulation of the Extreme Biofilm Formation ofInternational journal of molecular sciences · 2023Article
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- Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against HBiological procedures online · 2023Article
- Radioprotective countermeasures for radiation injury (Review).Molecular medicine reports · 2023Review
- SLICER: A Seamless Gene Deletion Method forBiodesign research · 2023Article
- Novel Exopolysaccharide from MarineMetabolites · 2022Article
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- The radiophiles of Deinococcaceae family: Resourceful microbes for innovative biotechnological applications.Current research in microbial sciences · 2022Review
- Radioprotection of deinococcal exopolysaccharide BRD125 by regenerating hematopoietic stem cells.Frontiers in oncology · 2022Article
- Biological Mitigation of Antibiotic Resistance Gene Dissemination by Antioxidant-Producing Microorganisms in Activated Sludge Systems.Environmental science & technology · 2021Article
- New Exopolysaccharides Produced byMicroorganisms · 2021Article
- Development and Validation of Enzyme-Linked Immunosorbent Assay for Group B Streptococcal Polysaccharide Vaccine.Vaccines · 2021Article
- Antioxidant potential and optimization of production of extracellular polysaccharide by Acinetobacter indicus M6.Journal, genetic engineering & biotechnology · 2021Article
- Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications.Molecules (Basel, Switzerland) · 2021Review
- Article
- Extremophilic Exopolysaccharides: Biotechnologies and Wastewater Remediation.Frontiers in microbiology · 2021Review
- Comparative genomics of wild-type and laboratory-evolved biofilm-overproducingMicrobial genomics · 2020Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deinococcus radiodurans shows extreme resistance to a range of remarkable environmental stresses. Deinococcal exopolysaccharide (DeinoPol) is a component of the cell wall, but its role in stress resistance has not yet been well-described. In this study, we isolated and characterized DeinoPol from Deinococcus radiodurans R1 strain and investigated its application as an antioxidant agent. Bioinformatic analysis indicated that dra0033, encoding an ExoP-like protein, was involved in DeinoPol biosynthesis, and dra0033 mutation significantly decreased survival rates in response to stresses. Purified DeinoPol consists of different monosaccharides and has a molecular weight of approximately 80 to 100 kDa. DeinoPol also demonstrates highly protective effects on human keratinocytes in response to stress-induced apoptosis by effectively scavenging ROS. Taken together, these findings indicate that DeinoPol is the first reported deinococcal exopolysaccharide that might be used in cosmetics and pharmaceuticals as a safe and attractive radical scavenger.
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