Evidence map›Paper›PMID 31919191›Full record

ArticleGenes & development2020

The microtubule regulator

Ernest J Monahan Vargas, Andrew J Matamoros, Jingyun Qiu, Calvin H Jan, Qin Wang, David Gorczyca, Tina W Han, Jonathan S Weissman, Yuh Nung Jan, Swati Banerjee and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Ernest J Monahan Vargas *Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Andrew J Matamoros *Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Jingyun Qiu *Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Calvin H JanDepartment of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California 94158, USA.
Qin WangRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
David GorczycaHoward Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94158, USA.
Tina W HanHoward Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94158, USA.
Jonathan S WeissmanDepartment of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California 94158, USA.
Yuh Nung JanHoward Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94158, USA.
Swati BanerjeeDepartment of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA.
Yuanquan SongRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Children's Hospital of Philadelphia · USHoward Hughes Medical Institute · USUniversity of California, San Francisco · USIntegrative Health Technologies (United States) · USUniversity of Pennsylvania · US

Funding

University of Pennsylvania Postdoctoral Opportunities in Research and TeachingK12GM081259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Janis K. Burkhardt · 2007 to 2026
$20.1M
Training Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9M
Dendrite morphogenesis, function and regenerationR35NS097227 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, YUH NUNG · 2017 to 2024
$5.1M
Graduate Training in Developmental BiologyT32HD083185 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato, Foteini Mourkioti · 2015 to 2026
$4.0M
Targeting Atr to promote regeneration and functional recovery after neural injuryR01NS107392 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SONG, YUANQUAN · 2018 to 2022
$1.9M
Mechanistic studies of novel factors regulating axon regeneration in the PNS/CNSR00NS088211 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SONG, YUANQUAN · 2016 to 2018
$728k
Mechanistic studies of novel factors regulating axon regeneration in the PNS/CNSK99NS088211 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SONG, YUANQUAN · 2014 to 2015
$190k
NICHD NIH HHS T32 HD083185NIGMS NIH HHS K12 GM081259NINDS NIH HHS K99 NS088211NINDS NIH HHS R00 NS088211NINDS NIH HHS R01 NS107392NINDS NIH HHS R35 NS097227NINDS NIH HHS T32 NS007413
6 · The paper itself

Abstract

Promoting axon regeneration in the central and peripheral nervous system is of clinical importance in neural injury and neurodegenerative diseases. Both pro- and antiregeneration factors are being identified. We previously reported that the Rtca mediated RNA repair/splicing pathway restricts axon regeneration by inhibiting the nonconventional splicing of

Indexed as

AnilidesAnimalsAxonsDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalHydroxamic AcidsMicrotubule-Associated ProteinsMicrotubulesNerve Tissue ProteinsProtein BindingRegenerationRNA SplicingSensory Receptor CellsAnilidesDrosophila Proteinsfutsch protein, DrosophilaHydroxamic Acidsmicrotubule-associated protein 1BMicrotubule-Associated ProteinsNerve Tissue Proteinsringer protein, Drosophilatubacinaxon regenerationdendritic arborization neuronDrosophilafutschHDAC6MAP1BmicrotubuleringerRtcaTPPP

Identifiers

PMID31919191
PMCPMC7000917
OpenAlexW2999082447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.