Evidence map›Paper›PMID 31919188›Full record

ArticleGenes & development2020

The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression.

Chunxia Zhang, Zhiyuan Chen, Qiangzong Yin, Xudong Fu, Yisi Li, Tomas Stopka, Arthur I Skoultchi, Yi Zhang

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 53 citations in OpenAlex.

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  13. SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Chunxia Zhang *Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Zhiyuan Chen *Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Qiangzong YinHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Xudong FuHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Yisi LiHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Tomas StopkaDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Arthur I SkoultchiDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Yi ZhangHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Boston Children's Hospital · USAlbert Einstein College of Medicine · USHoward Hughes Medical Institute · USHarvard Stem Cell Institute · US

Funding

Understanding mechanism and improving efficiency of somatic cell nuclear transferR01HD092465 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI ZHANG, YI · 2017 to 2021
$2.4M
Functions of Mammalian H1 Linker Histones in Gene Regulation and DevelopmentR01GM116143 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SKOULTCHI, ARTHUR I · 2015 to 2018
$1.9M
Howard Hughes Medical InstituteNICHD NIH HHS R01 HD092465NIGMS NIH HHS R01 GM116143
6 · The paper itself

Abstract

Oocytes are indispensable for mammalian life. Thus, it is important to understand how mature oocytes are generated. As a critical stage of oocytes development, meiosis has been extensively studied, yet how chromatin remodeling contributes to this process is largely unknown. Here, we demonstrate that the ATP-dependent chromatin remodeling factor Snf2h (also known as Smarca5) plays a critical role in regulating meiotic cell cycle progression. Females with oocyte-specific depletion of

Indexed as

Adenosine TriphosphatasesAnimalsChromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneFemaleGene Expression Regulation, DevelopmentalGene Knockout TechniquesMaturation-Promoting FactorMeiosisMesothelinMiceOocytesOogenesisTranscriptomeAdenosine TriphosphatasesChromosomal Proteins, Non-HistoneMaturation-Promoting FactorMesothelinMsln protein, mouseSmarca5 protein, mousechromatin remodelinggerm cell developmentmeiotic resumptionMPF activitySnf2htranscriptional regulation

Identifiers

PMID31919188
PMCPMC7000916
OpenAlexW2999667388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.