ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Neurofeedback-Linked Suppression of Cortical β Bursts Speeds Up Movement Initiation in Healthy Motor Control: A Double-Blind Sham-Controlled Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Trial
- Network state transitions under deep brain stimulation: A Wilson-Cowan model of Parkinson's Disease.Journal of computational neuroscience · 2026Article
- Disease modification in advanced Parkinson's disease: a review and roadmap for paving the way for next-generation interventions.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Mapping Executive Function Performance Based on Resting-State EEG in Healthy Individuals: A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.Surgical neurology international · 2026Review
- Article
- Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain-Sense Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Non-invasive brain stimulation to modulate neural activity in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy.NPJ Parkinson's disease · 2025Article
- Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control.Nature communications · 2024Article
- Synaptic Changes in Pallidostriatal Circuits Observed in the Parkinsonian Model Triggers Abnormal Beta Synchrony with Accurate Spatio-temporal Properties across the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson's disease.Brain : a journal of neurology · 2023Article
- Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Average power and burst analysis revealed complementary information on drug-related changes of motor performance in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Finely-tuned gamma oscillations: Spectral characteristics and links to dyskinesia.Experimental neurology · 2022Review
- Novel approaches for quantifying beta synchrony in Parkinson's disease.Experimental brain research · 2022Review
- Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease.Brain : a journal of neurology · 2022Article
- Functional Interactions Between the Parafascicular Thalamic Nucleus and Motor Cortex Are Altered in Hemiparkinsonian Rat.Frontiers in aging neuroscience · 2022Article
- Reaching and Grasping Movements in Parkinson's Disease: A Review.Journal of Parkinson's disease · 2022Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
Bursts of beta frequency band activity in the basal ganglia of patients with Parkinson's disease (PD) are associated with impaired motor performance. Here we test in human adults whether small variations in the timing of movement relative to beta bursts have a critical effect on movement velocity and whether the cumulative effects of multiple beta bursts, both locally and across networks, matter. We recorded local field potentials from the subthalamic nucleus (STN) in 15 PD patients of both genders OFF-medication, during temporary lead externalization after deep brain stimulation surgery. Beta bursts were defined as periods exceeding the 75th percentile amplitude threshold. Subjects performed a visual cued joystick reaching task, with the visual cue being triggered in real time with different temporal relationships to bursts of STN beta activity. The velocity of actions made in response to cues prospectively triggered by STN beta bursts was slower than when responses were not time-locked to recent beta bursts. Importantly, slow movements were those that followed multiple bursts close to each other within a trial. In contrast, small differences in the delay between the last burst and movement onset had no significant impact on velocity. Moreover, when the overlap of bursts between the two STN was high, slowing was more pronounced. Our findings suggest that the cumulative, but recent, history of beta bursting, both locally and across basal ganglia networks, may impact on motor performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.