Evidence map›Paper›PMID 31919098›Full record

ArticleThe Journal of biological chemistry2020

The phosphatidic acid pathway enzyme PlsX plays both catalytic and channeling roles in bacterial phospholipid synthesis.

Diego E Sastre, André A Pulschen, Luis G M Basso, Jhonathan S Benites Pariente, Caterina G C Marques Netto, Federico Machinandiarena, Daniela Albanesi, Marcos V A S Navarro, Diego de Mendoza, Frederico J Gueiros-Filho

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Diversity of grass-associated Nitrospirillum and proposal of six novel species.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  4. Fatty acid synthesis and utilization in gram-positive bacteria: insights fromMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  5. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Growth ofmSphere · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Diego E SastreInstituto de Química, Departamento de Bioquímica, Universidade de São Paulo, São Paulo, SP 05508-000, Brazil; Grupo de Biofísica Molecular "Sergio Mascarenhas," Instituto de Física de São Carlos, Departamento de Biofísica Molecular, Universidade de São Paulo, São Carlos, SP 13560-970, Brazil.
André A PulschenInstituto de Química, Departamento de Bioquímica, Universidade de São Paulo, São Paulo, SP 05508-000, Brazil.
Luis G M BassoDepartamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-901, Brazil.
Jhonathan S Benites ParienteInstituto de Química, Departamento de Bioquímica, Universidade de São Paulo, São Paulo, SP 05508-000, Brazil.
Caterina G C Marques NettoDepartamento de Química, Universidade Federal de São Carlos (UFSCar), São Carlos, SP 13565-905, Brazil.
Federico MachinandiarenaInstituto de Biología Molecular y Celular de Rosario (IBR), CONICET and Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe S2002LRK, Argentina.
Daniela AlbanesiInstituto de Biología Molecular y Celular de Rosario (IBR), CONICET and Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe S2002LRK, Argentina.
Marcos V A S NavarroGrupo de Biofísica Molecular "Sergio Mascarenhas," Instituto de Física de São Carlos, Departamento de Biofísica Molecular, Universidade de São Paulo, São Carlos, SP 13560-970, Brazil.
Diego de MendozaInstituto de Biología Molecular y Celular de Rosario (IBR), CONICET and Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe S2002LRK, Argentina. Electronic address: demendoza@ibr-conicet.gov.ar.
Frederico J Gueiros-FilhoInstituto de Química, Departamento de Bioquímica, Universidade de São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address: fgueiros@iq.usp.br.
Universidade de São Paulo · BRConsejo Nacional de Investigaciones Científicas y Técnicas · ARUniversidade de Ribeirão Preto · BRUniversidade Federal de São Carlos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PlsX is the first enzyme in the pathway that produces phosphatidic acid in Gram-positive bacteria. It makes acylphosphate from acyl-acyl carrier protein (acyl-ACP) and is also involved in coordinating phospholipid and fatty acid biosyntheses. PlsX is a peripheral membrane enzyme in

Indexed as

Bacillus subtilisBacterial ProteinsCatalysisEscherichia coliFatty AcidsLipogenesisMetabolic Networks and PathwaysPhosphatidic AcidsPhospholipidsBacterial ProteinsFatty AcidsPhosphatidic AcidsPhospholipidsplsX protein, bacteriaacylphosphateacyltransferaseglycerophospholipidGram-positive bacterialipid binding proteinmembrane biogenesisPlsXsubstrate channeling

Identifiers

PMID31919098
PMCPMC7029103
OpenAlexW2998871150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.