Evidence map›Paper›PMID 31918579›Full record

ArticleFuture microbiology2020

Ceftobiprole versus daptomycin in

Kamal Hamed, Marc Engelhardt, Mark E Jones, Mikael Saulay, Thomas L Holland, Harald Seifert, Vance G Fowler

Registry-linked trialOpen access · hybridAbstract readClinical Trial Protocol
In one paragraph

Article in Future microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03138733 (A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03138733 phase3completednot on this map

A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis

TypeinterventionalSponsorBasilea PharmaceuticaRan2018 to 2022Enrolled390ConditionsStaphylococcus Aureus BacteremiaArmsCeftobiprole medocaril, Daptomycin
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Treatment of Methicillin-ResistantMedicines (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Which trial do we need? Next-generation sequencing to individualize therapy in Staphylococcus aureus bacteraemia.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
    Article
  7. Persistent Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023
    Review
  8. New Approaches to Manage Infections in Transplant Recipients: Report From the 2023 GTI (Infection and Transplantation Group) Annual Meeting.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  9. Article
  10. Persistent Methicilin-Resistant Staphylococcus aureus Bacteremia: Resetting the Clock for Optimal Management.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  11. JAC-antimicrobial resistance · 2022
    Article
  12. Investigational agents for the treatment of methicillin-resistantExpert opinion on investigational drugs · 2022
    Article
  13. Review
  14. Article
  15. Ceftobiprole: a clinical view.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021
    Review
  16. Review
  17. A case study onJAC-antimicrobial resistance · 2020
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Kamal HamedBasilea Pharmaceutica International Ltd, Basel, Switzerland.ORCID 0000-0003-1896-9736
Marc EngelhardtBasilea Pharmaceutica International Ltd, Basel, Switzerland.
Mark E JonesBasilea Pharmaceutica International Ltd, Basel, Switzerland.
Mikael SaulayBasilea Pharmaceutica International Ltd, Basel, Switzerland.
Thomas L HollandDepartment of Medicine, Duke University Medical Center & Duke Clinical Research Institute, Durham, NC, USA.
Harald SeifertInstitute for Medical Microbiology, Immunology & Hygiene, University Hospital of Cologne, Cologne, Germany.
Vance G FowlerDepartment of Medicine, Duke University Medical Center & Duke Clinical Research Institute, Durham, NC, USA.
Basilea Pharmaceutica (Switzerland) · CHClinical Research Institute · USGerman Center for Infection Research · DEGTx (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although

Indexed as

AdultBacteremiaCephalosporinsClinical Trials as TopicDaptomycinDouble-Blind MethodDrug Resistance, Multiple, BacterialFemaleHospitalizationHumansMaleMethicillin-Resistant Staphylococcus aureusMulticenter Studies as TopicRandomized Controlled Trials as TopicStaphylococcal InfectionsStaphylococcus aureusceftobiproleCephalosporinsDaptomycinbacteremiaceftobiproledaptomycindouble-blindinfective endocarditisnoninferiorityPhase IIIprotocolrandomizedStaphylococcus aureus

Identifiers

PMID31918579
PMCPMC7046132
OpenAlexW2998896869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.