Evidence map›Paper›PMID 31918312›Full record

ArticleEnvironmental research2020

Serum concentrations of DDE, PCBs, and other persistent organic pollutants and mammographic breast density in Triana, Alabama, a highly exposed population.

J A Rusiecki, H Denic-Roberts, C Byrne, J Cash, C F Raines, L A Brinton, S H Zahm, T Mason, M R Bonner, A Blair and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

J A RusieckiDepartment of Preventive Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address: jennifer.rusiecki@usuhs.edu.
H Denic-RobertsDepartment of Preventive Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
C ByrneDepartment of Preventive Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
J CashUniversity of Alabama in Huntsville, College of Nursing, Huntsville, AL, USA.
C F RainesUniversity of Alabama in Huntsville, College of Nursing, Huntsville, AL, USA.
L A BrintonNational Cancer Institute Retired, USA.
S H ZahmSheila Zahm Consulting, Formerly at National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
T MasonUniversity of South Florida, College of Public Health, Tampa, FL, USA.
M R BonnerDepartment of Epidemiology and Environmental Health, State University of New York, Buffalo, NY, USA.
A BlairNational Cancer Institute Retired, Scientist Emeritus, USA.
R HooverNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
National Cancer Institute · USUniformed Services University of the Health Sciences · USUniversity of Alabama in Huntsville · USDivision of Cancer Epidemiology and GeneticsFlorida College · USHenry M. Jackson Foundation · USUniversity at Buffalo, State University of New York · US

Funding

Impact of environmental metal/metalloid exposures on mammographic breast density, a marker of breast cancerU01ES026132 · NIEHS · GEORGETOWN UNIVERSITY · PI BYRNE, CELIA, MARTIN, MARYBETH · 2015 to 2019
$4.5M
NIEHS NIH HHS U01 ES026132
6 · The paper itself

Abstract

introductionAlthough some persistent organic pollutants (POPs) are considered human carcinogens, results from studies evaluating exposures and breast cancer risk have been inconsistent, potentially related to varying ages at exposure. Additionally, few studies evaluated the association between POPs exposure and mammographic breast density (MBD), an intermediate biomarker of breast cancer risk. We carried out a cross-sectional study to investigate associations between serum POPs concentrations and MBD measured in 1998 in female residents of Triana, Alabama, in a predominately African American population with high POPs exposures, particularly to p,p'-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane).

methodsWe measured lipid-adjusted serum concentrations (ng/g lipid) of p,p'-DDT and its main metabolite p,p'-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene), polychlorinated biphenyls (PCBs), β-hexachlorocyclohexane (β-HCCH), heptachlor epoxide, oxychlordane, trans-nonachlor, mirex, and aldrin for each woman in our study (n = 210). We also measured two MBD metrics, percent MBD (%MBD) and area of MBD (aMBD). Using adjusted Spearman correlation coefficients (r

resultsAmong all women, we found no correlation between p,p'-DDE and %MBD, but after age stratification and exclusion of HRT users, there was a suggestion of a difference by age group, with younger women having a weak positive correlation (r

conclusionsIn this population, despite high exposures to p,p'-DDT and thus high serum concentrations of its main metabolite, p,p'-DDE, we did not find strong evidence of a positive association with MBD. In fact, there was some evidence of a negative association among older women for p,p'-DDE; a similar pattern was found for β-HCCH. However, younger women with higher serum levels of PCBs, heptachlor epoxide, oxychlordane, and trans-nonachlor, who were likely exposed in early life, had higher MBD. These findings should be replicated in larger studies.

Indexed as

Breast DensityDichlorodiphenyl DichloroethyleneEnvironmental PollutantsHydrocarbons, ChlorinatedPolychlorinated BiphenylsAgedAlabamaCross-Sectional StudiesFemaleHumansMiddle AgedDichlorodiphenyl DichloroethyleneEnvironmental PollutantsHydrocarbons, ChlorinatedPolychlorinated BiphenylsDDEDDTMammographic breast densityPCBsPersistent organic pollutantsTriana

Identifiers

PMID31918312
PMCPMC7032000
OpenAlexW2998340607

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.