Evidence map›Paper›PMID 31918173›Full record

ArticleOral oncology2020

Molecular biology of oral cavity squamous cell carcinoma.

Phillip J Hsu, Kenneth Yan, Hailing Shi, Evgeny Izumchenko, Nishant Agrawal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Phillip J HsuMedical Scientist Training Program, The University of Chicago, Chicago, IL 60637, USA.
Kenneth YanSection of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA.
Hailing ShiDepartment of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
Evgeny IzumchenkoSection of Hematology Oncology, Department of Medicine, University of Chicago Medicine, Chicago, IL 60637, USA.
Nishant AgrawalSection of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA. Electronic address: na@uchicago.edu.

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Multi-analyte Approach for Earlier Detection of Cancers in Non Plasma BiofluidsU01CA230691 · NCI · JOHNS HOPKINS UNIVERSITY · PI Nishant Agrawal, CHETAN BETTEGOWDA · 2018 to 2026
$6.7M
Interrogating malignant gliomas using released tumor DNA in cerebrospinal fluidR37CA230400 · NCI · JOHNS HOPKINS UNIVERSITY · PI BETTEGOWDA, CHETAN · 2018 to 2024
$2.6M
NCI NIH HHS R37 CA230400NCI NIH HHS U01 CA230691NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

Oral cavity squamous cell carcinoma (OCSCC) is a heterogeneous and complex disease that arises due to dysfunction of multiple molecular signaling pathways. Recent advances in high-throughput genetic sequencing technologies coupled with innovative analytical techniques have begun to characterize the molecular determinants driving OCSCC. An understanding of the key molecular signaling networks underlying the initiation and progression of is essential for informing treatment of the disease. In this chapter, we discuss recent findings of key genes altered in OCSCC and potential treatments targeting these genes.

Indexed as

beta CateninCarcinoma, Squamous CellCyclin D1Cyclin-Dependent Kinase Inhibitor p16Epigenesis, GeneticErbB ReceptorsHigh-Throughput Nucleotide SequencingHumansImmunotherapyMouth NeoplasmsNeoplasm InvasivenessNeoplasm MetastasisNeoplasm ProteinsOncogene Protein v-aktPhosphatidylinositol 3-KinaseReceptor, Notch1beta CateninCCND1 protein, humanCTNNB1 protein, humanCyclin D1Cyclin-Dependent Kinase Inhibitor p16ErbB ReceptorsMTOR protein, humanNeoplasm ProteinsNOTCH1 protein, humanOncogene Protein v-aktPhosphatidylinositol 3-KinaseReceptor, Notch1Retinoblastoma ProteinTOR Serine-Threonine KinasesTumor Suppressor Protein p53Cancer geneticsEpigeneticsHead and neck cancerHead and neck squamous cell carcinomaHNSCCImmunotherapyMolecular biology of oral cavity squamous cell carcinomaOral cancerOral cavity cancerSquamous cell carcinoma

Identifiers

PMID31918173
PMCPMC7659372

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.