ArticleBlood advances2020
Metabolic syndrome increases risk of venous thromboembolism recurrence after acute deep vein thrombosis.
Article in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07119658 (Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- The association between body mass index and lower extremity deep venous abnormalities identified by computed tomography venography.Frontiers in public health · 2026Article
- Managing patients with a history of arterial disease and new venous thromboembolism.Hematology. American Society of Hematology. Education Program · 2025Article
- The Interplay Between Obesity and Venous Thromboembolism: From Molecular Aspects to Clinical Issue.International journal of molecular sciences · 2025Review
- Association between serum triglyceride levels and venous thrombosis risk in older Chinese patients with fractures: a retrospective cross-sectional study.Lipids in health and disease · 2025Article
- Vegan and Plant-Based Diets in the Management of Metabolic Syndrome: A Narrative Review from Anti-Inflammatory and Antithrombotic Perspectives.Nutrients · 2025Review
- Metabolic syndrome, adipokines, coagulation factors, and venous thromboembolism: a two-step Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
- Changes in body mass index following venous thromboembolism in children: a prospective cohort study.Research and practice in thrombosis and haemostasis · 2025Article
- Non-demographic dependent mechanisms of DVT formation in patients with traumatic limb fractures: an exploratory cohort study based on limited variable matching.American journal of translational research · 2025Article
- Overview of Venous Thromboembolism and Emerging Therapeutic Technologies Based on Nanocarriers-Mediated Drug Delivery Systems.Molecules (Basel, Switzerland) · 2024Review
- While the Incidence of Venous Thromboembolism After Shoulder Arthroscopy Is Low, the Risk Factors Are a Body Mass Index Greater than 30 and Hypertension.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism.Thrombosis and haemostasis · 2023Article
- Basic science research opportunities in thrombosis and hemostasis: Communication from the SSC of the ISTH.Journal of thrombosis and haemostasis : JTH · 2022Article
- Review
- Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms.Frontiers in endocrinology · 2022Review
- Acceptability of Exercise in Urban Emergency Department Patients With Metabolic Syndrome, Including a Subset With Venous Thromboembolism.Journal of patient experience · 2022Article
- Direct oral anticoagulant therapy in patients with morbid obesity after intermediate- or high-risk pulmonary emboli.ERJ open research · 2021Article
- The Role of Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer.Journal of diabetes and metabolic disorders · 2020Review
- Fibrinolytics for the treatment of pulmonary embolism.Translational research : the journal of laboratory and clinical medicine · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
An improved understanding of which patients are at higher risk of recurrent venous thromboembolism (VTE) is important to designing interventions to reduce degraded quality of life after VTE. Although metabolic syndrome (MetS), the clustering of hypertension, hyperlipidemia, diabetes mellitus, and obesity has been associated with a hypofibrinolytic state, data linking VTE recurrence with MetS remain limited. The purpose of this study was to measure the prevalence of MetS in patients with deep vein thrombosis (DVT) across a large population and determine its effect on VTE recurrence. This was a retrospective analysis of a large statewide database from 2004 to 2017. We measured the frequency with which patients with DVT carried a comorbid International Coding of Diseases diagnosis of MetS components. Association of MetS with VTE recurrence was tested with a multiple logistic regression model and VTE recurrence as the dependent variable. Risk of VTE recurrence conferred by each MetS component was assessed by Kaplan-Meier curves with the log-rank statistic. A total of 151 054 patients with DVT were included in this analysis. Recurrence of VTE occurred in 17% overall and increased stepwise with each criterion for MetS. All 4 components of MetS had significant adjusted odds ratios (OR) for VTE recurrence, with hyperlipidemia having the largest (OR, 1.8), representing the 4 largest ORs of all possible explanatory variables. All 4 MetS variables were significant on Kaplan-Meier analysis for recurrence of VTE. These data imply a role for appropriate therapies to reduce the effects of MetS as a way to reduce risk of VTE recurrence.
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Registered trials
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