Evidence map›Paper›PMID 31917832›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

"SILVAMP TB LAM" Rapid Urine Tuberculosis Test Predicts Mortality in Patients Hospitalized With Human Immunodeficiency Virus in South Africa.

Bianca Sossen, Tobias Broger, Andrew D Kerkhoff, Charlotte Schutz, Andre Trollip, Emmanuel Moreau, Samuel G Schumacher, Rosie Burton, Amy Ward, Robert J Wilkinson and 4 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bianca SossenWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Republic of South Africa.
Tobias BrogerFoundational for Innovative Diagnostics, Geneva, Switzerland.
Andrew D KerkhoffDivision of HIV, Infectious Diseases and Global Medicine at Zuckerberg San Francisco General Hospital and Trauma Center, Department of Medicine, University of California, San Francisco, California, USA.
Charlotte SchutzWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Republic of South Africa.
Andre TrollipFoundational for Innovative Diagnostics, Geneva, Switzerland.
Emmanuel MoreauFoundational for Innovative Diagnostics, Geneva, Switzerland.
Samuel G SchumacherFoundational for Innovative Diagnostics, Geneva, Switzerland.
Rosie BurtonSouthern African Medical Unit, Médecins sans Frontières, Cape Town, South Africa.
Amy WardWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Republic of South Africa.
Robert J WilkinsonWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Republic of South Africa.
David A BarrWellcome Trust Liverpool Glasgow Centre for Global Health Research, University of Liverpool, United Kingdom.
Mark P NicolDivision of Infection and Immunity, School of Biomedical Sciences, University of Western Australia, Perth, Australia.
Claudia M DenkingerFoundational for Innovative Diagnostics, Geneva, Switzerland.
Graeme MeintjesWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Republic of South Africa.

Funding

Training in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4M
Inflammatory determinants of disease severity and treatment outcome in TB patientsU01AI115940 · NIAID · UNIVERSITY OF CAPE TOWN · PI SHER, ALAN, WILKINSON, ROBERT JOHN · 2015 to 2019
$1.1M
Cancer Research UK FC0010218Gates Foundation OPP1105925NIAID NIH HHS T32 AI060530NIAID NIH HHS U01 AI115940Wellcome Trust 085251Wellcome Trust 088316Wellcome Trust 088590Wellcome Trust 098316Wellcome Trust 203135/Z/16/ZWellcome Trust FC0010218
6 · The paper itself

Abstract

Reducing diagnostic delay is key toward decreasing tuberculosis-associated deaths in people living with human immunodeficiency virus. In tuberculosis patients with retrospective urine testing, the point-of-care Fujifilm SILVAMP TB LAM (FujiLAM) could have rapidly diagnosed tuberculosis in up to 89% who died. In FujiLAM negative patients, the probability of 12-week survival was 86-97%.

Indexed as

HIV InfectionsTuberculosisDelayed DiagnosisHIVHumansLipopolysaccharidesRetrospective StudiesSensitivity and SpecificitySouth AfricalipoarabinomannanLipopolysaccharidesHIVlipoarabinomannanmortalitypoint-of-careTuberculosis

Identifiers

PMID31917832
PMCPMC8240995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.