ArticlePloS one2020
Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Torque teno virus: a potential marker of immune reconstitution in youths with vertically acquired HIV.Scientific reports · 2024Observational
- Article
- High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients.Viruses · 2024Article
- DNA from multiple viral species is associated with Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Maternal plasma and salivary anelloviruses in pregnancy and preterm birth.Frontiers in medicine · 2023Article
- Viruses of the oral cavity: Prevalence, pathobiology and association with oral diseases.Reviews in medical virology · 2022Review
- Survey of Viral Reactivations in Elite Athletes: A Case-Control Study.Pathogens (Basel, Switzerland) · 2021Article
- Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.PloS one · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Torque teno virus (TTV) is an unenveloped, circular, single stranded DNA virus with a genome size of approximately 3.8 kb. Previous studies have demonstrated varying grades of association between TTV DNA levels and immune deficiencies related to age, chronic infections and cancer. Alzheimer's disease (AD) has been related to persistent viral infections such as HSV-1 and CMV, but it is not known whether TTV viral load could serve as a functional biomarker of cellular immunity in this setting. Therefore, the objective of this study was to investigate whether TTV infection and viral load is related to AD status, CMV immunity, systemic inflammation or HLA types connected to anti-viral immunity. A total of 50 AD subjects and 51 non-demented controls were included in the study. AD subjects were diagnosed according to NINCDS-ADRDA and DSM-IV criteria and neuroradiologic findings were consistent with the diagnosis. TTV viral load was analyzed in plasma samples using a quantitative real-time PCR. Using a cut-off for TTV status at 200 copies/ml, 88% (89/101) of the study subjects were classified as TTV positive. TTV viral load significantly increased with age (beta 0.049 per year, p<0.001) but significantly decreased in relation to CMV IgG levels (beta -0.022 per 1000 units, p = 0.005) and HLA-B27 positivity (beta -0.53, p = 0.023). In conclusion, TTV immune control is not significantly affected by AD status, but appears related to age, CMV humoral immune response and HLA type.
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