Evidence map›Paper›PMID 31917418›Full record

ReviewPain medicine (Malden, Mass.)2020

Understanding Buprenorphine for Use in Chronic Pain: Expert Opinion.

Lynn Webster, Jeffrey Gudin, Robert B Raffa, Jay Kuchera, Richard Rauck, Jeffrey Fudin, Jeremy Adler, Theresa Mallick-Searle

Open access · hybridAbstract readConsensus StatementReview
In one paragraph

Review in Pain medicine (Malden, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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  18. Buprenorphine Is Associated With Lower Home Opioid Use and Acute Care Utilization in Sickle Cell Disease.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025
    Article
  19. Subcutaneous Buprenorphine Is an Acceptable Preoperative Analgesic in Pregnant Ewes Undergoing Hysterotomy (Ovis aries).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Lynn WebsterPRA Health Sciences, San Diego, California.
Jeffrey GudinDepartment of Anesthesiology and Pain Management, Englewood Hospital and Medical Center, Englewood, New Jersey; Rutgers New Jersey Medical School, Newark, New Jersey.
Robert B RaffaCollege of Pharmacy, The University of Arizona Health Sciences, Tucson, Arizona.
Jay KucheraResolute Pain Solutions, Okeechobee, Florida.
Richard RauckCarolinas Pain Institute, Winston-Salem, North Carolina.
Jeffrey FudinRemitigate LLC, Delmar, New York; Western New England University College of Pharmacy, Springfield, Massachusetts.
Jeremy AdlerPacific Pain Medicine Consultants, Encinitas, California.
Theresa Mallick-SearleDivision of Pain Medicine, Stanford Medicine Outpatient Center, Redwood City, California, USA.
Calmar Pain Relief · USCarolinas Pain Institute · USPRA Health Sciences · USRutgers, The State University of New Jersey · USStanford Medicine · USUniversity of Arizona · USWestern New England University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAn expert panel convened to reach a consensus on common misconceptions surrounding buprenorphine, a Schedule III partial µ-opioid receptor agonist indicated for chronic pain. The panel also provided clinical recommendations on the appropriate use of buprenorphine and conversion strategies for switching to buprenorphine from a full µ-opioid receptor agonist for chronic pain management.

methodsThe consensus panel met on March 25, 2019, to discuss relevant literature and provide recommendations on interpreting buprenorphine as a partial µ-opioid receptor agonist, prescribing buprenorphine before some Schedule II, III, or IV options, perioperative/trauma management of patients taking buprenorphine, and converting patients from a full µ-opioid receptor agonist to buprenorphine.

resultsThe panel recommended that buprenorphine's classification as a partial µ-opioid receptor agonist not be clinically translated to mean partial analgesic efficacy. The panel also recommended that buprenorphine be considered before some Schedule II, III, or IV opioids in patients with a favorable risk/benefit profile on the basis of metabolic factors, abuse potential, and tolerability and that buprenorphine be continued during the perioperative/trauma period. In addition, switching patients from a full µ-opioid receptor agonist to buprenorphine should be considered with no weaning period at starting doses that are based on the previous opioid dose.

conclusionsThese recommendations provide a framework for clinicians to address most clinical scenarios regarding buprenorphine use. The overall consensus of the panel was that buprenorphine is a unique Schedule III opioid with favorable pharmacologic properties and a safety profile that may be desirable for chronic pain management.

Indexed as

Analgesics, OpioidBuprenorphineChronic PainDrug SubstitutionHumansReceptors, Opioid, muAnalgesics, OpioidBuprenorphineReceptors, Opioid, muBuprenorphineChronic PainOpioidPartial AgonistSchedule IIIµ-Opioid Receptor

Identifiers

PMID31917418
PMCPMC7139205
OpenAlexW2999420193

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.