Evidence map›Paper›PMID 31917219›Full record

ArticleThe journal of pain

Alternative Splicing of Nrcam Gene in Dorsal Root Ganglion Contributes to Neuropathic Pain.

Lingli Liang, Shaogen Wu, Corinna Lin, Yun-Juan Chang, Yuan-Xiang Tao

Open access · bronzeAbstract read
In one paragraph

Article in The journal of pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. DNMT3a Downregulation Ttriggered Upregulation of GABAAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Review
  3. Rbfox1 regulates alternative splicing of Nrcam in primary sensory neurons to mediate peripheral nerve injury-induced neuropathic pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
  4. Spying on specific splicing in spinal nerve injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
  5. Article
  6. FUS Contributes to Nerve Injury-Induced Nociceptive Hypersensitivity by Activating NF-κB Pathway in Primary Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Alternative splicing of lncRNAs in human diseases.American journal of cancer research · 2021
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lingli LiangDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey.
Shaogen WuDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey.
Corinna LinDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey.
Yun-Juan ChangOffice of advanced research computing, Rutgers, The State University of New Jersey, Newark, New Jersey.
Yuan-Xiang TaoDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey; Department of Cell Biology & Molecular Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey; Department of Physiology, Pharmacology & Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey. Electronic address: yuanxiang.tao@njms.rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

The Role of Endothelin-1 in Sickle Cell DiseaseU01HL117684 · NHLBI · AUGUSTA UNIVERSITY · PI KUTLAR, ABDULLAH, MEILER, STEFFEN · 2013 to 2017
$8.1M
Discovery and validation of a new long noncoding RNA as a novel target for neuropathic painRF1NS113881 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DAVIDSON, STEVE, TAO, YUAN-XIANG · 2019 to 2019
$3.5M
Role of dorsal root ganglion FTO, a RNA demethylase, in neuropathic painR01NS111553 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI TAO, YUAN-XIANG · 2019 to 2023
$2.5M
Dissection of a new spinal cord circuit in pain sensationR01NS094224 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUO, WENQIN · 2016 to 2020
$2.5M
Epigenetic regulation of neuropathic pain: Role of DRG histone methyltransferase G9aR01NS094664 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2016 to 2020
$2.0M
mTOR, a new target for opioid-induced tolerance and hyperalgesiaR01DA033390 · NIDA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2013 to 2017
$1.8M
NHLBI NIH HHS U01 HL117684NIDA NIH HHS R01 DA033390NINDS NIH HHS R01 NS094224NINDS NIH HHS R01 NS094664NINDS NIH HHS R01 NS111553NINDS NIH HHS RF1 NS113881
6 · The paper itself

Abstract

NrCAM, a neuronal cell adhesion molecule in the L1 family of the immunoglobulin superfamily, is subjected to extensively alternative splicing and involved in neural development and some disorders. The aim of this study was to explore the role of Nrcam mRNA alternative splicing in neuropathic pain. A next generation RNA sequencing analysis of dorsal root ganglions (DRGs) showed the differential expression of two splicing variants of Nrcam, Nrcam

Indexed as

Cell Adhesion MoleculesHyperalgesiaNeuralgiaAlternative SplicingAnimalsGanglia, SpinalInjections, SpinalLigationMaleMiceMice, Inbred C57BLOligonucleotides, AntisenseSequence Analysis, RNASpinal NervesCell Adhesion MoleculesNrcam protein, mouseOligonucleotides, Antisensealternative splicingdorsal root ganglionneuropathic painNrCAMspinal nerve ligation

Identifiers

PMID31917219
PMCPMC7380119
OpenAlexW2999749940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.