Evidence map›Paper›PMID 31917153›Full record

ArticleNeuropharmacology2020

Attenuated dopamine receptor signaling in nucleus accumbens core in a rat model of chemically-induced neuropathy.

Dana E Selley, Matthew F Lazenka, Laura J Sim-Selley, Julie R Secor McVoy, David N Potter, Elena H Chartoff, William A Carlezon, S Stevens Negus

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dana E SelleyDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address: dana.selley@vcuhealth.org.
Matthew F LazenkaDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Laura J Sim-SelleyDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Julie R Secor McVoyDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA.
David N PotterBehavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, 02478, USA.
Elena H ChartoffBehavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, 02478, USA.
William A CarlezonBehavioral Genetics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, 02478, USA.
S Stevens NegusDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Virginia Commonwealth University · USHarvard University · US

Funding

Neurobiology and Treatment of PainR01NS070715 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEGUS, SIDNEY S, SELLEY, DANA E · 2009 to 2018
$3.3M
NINDS NIH HHS R01 NS070715
6 · The paper itself

Abstract

Neuropathy is major source of chronic pain that can be caused by mechanically or chemically induced nerve injury. Intraplantar formalin injection produces local necrosis over a two-week period and has been used to model neuropathy in rats. To determine whether neuropathy alters dopamine (DA) receptor responsiveness in mesolimbic brain regions, we examined dopamine D

Indexed as

AnimalsConditioning, OperantDisease Models, AnimalDopamine AgonistsDopamine AntagonistsDose-Response Relationship, DrugFormaldehydeMaleNeuralgiaNucleus AccumbensRatsRats, Sprague-DawleyReceptors, Dopamine D1Receptors, Dopamine D2Signal TransductionDopamine AgonistsDopamine AntagonistsDrd1 protein, ratDRD2 protein, ratFormaldehydeReceptors, Dopamine D1Receptors, Dopamine D2Adenylyl cyclaseAutoreceptorDopamineG-proteinNeuropathic painNucleus accumbens

Identifiers

PMID31917153
PMCPMC7654441
OpenAlexW2999234526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.