ReviewJournal of optometry
A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus.
Review in Journal of optometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Utility of artificial intelligence in the diagnosis and management of keratoconus: a systematic review.Frontiers in ophthalmology · 2024Pooled it
- Prevalence and risk factors of keratoconus among school children in Oman: a population-based study.BMC ophthalmology · 2026Article
- Underestimation of Intraocular Pressure (IOP) After LASIK and PRK: Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Combination of tissue-derived and shape-based parameters for subclinical keratoconus detection.Biomedical optics express · 2026Article
- Review
- Clinical Outcomes and Complications After INTACS Implantation in Keratoconus: A Systematic Review.Journal of clinical medicine · 2026Review
- Bacterial synthesis of personalized biomimetic biological cornea.Bioactive materials · 2026Article
- The role of corneal epithelial thickness parameters with different degrees of keratoconus in the diagnosis of keratoconus.Molecular vision · 2026Article
- Genetic and immune landscape of keratoconus: insights from Mendelian randomization analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Machine learning-assisted early detection of keratoconus: a comparative analysis of corneal topography and biomechanical data.Scientific reports · 2025Article
- Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters.Bioengineering (Basel, Switzerland) · 2025Article
- Constructing a disease-specific ceRNA coregulatory network for keratoconus diagnosis and landscape of the immune environment.International ophthalmology · 2025Article
- Corneal Epithelial Thickness Maps in Eyes with Mild and Moderate Keratoconus.Journal of clinical medicine · 2025Article
- Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.Journal of clinical medicine · 2025Review
- Keratoconus in children in Tunisia: Epidemiological, clinical and therapeutic features.La Tunisie medicale · 2025Article
- Comparative Assessment of Corneal Imaging Devices for Pediatric Patients: Evaluating Keratometric Measurements and Wavefront Aberrations.Journal of ophthalmic & vision research · 2025Article
- Digital transformation of care for keratoconus patients: ML modeling structural outcomes of corneal collagen cross-linking.Frontiers in medicine · 2025Article
- Individual Risk Assessment and Prognostication of Outcomes After Corneal Cross-Linking.Journal of ophthalmology · 2025Article
- Topographic factors associated with anterior chamber angle narrowing in patients with keratoconus.International journal of ophthalmology · 2025Article
- The Role of Pentacam Random Forest Index in Detecting Subclinical Keratoconus in a Chinese Cohort.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKeratoconus (KC) is a corneal ectasia characterised by steepening corneal curvature, changes in refractive error and corneal thickness that result in visual impairment. Early signs of KC include displacement of the thinnest part of the cornea from the central position, changes in the corneal epithelial layer cell distribution, variations in the anterior corneal astigmatism/posterior corneal astigmatism relationship and a variation in corneal thickness. It is important that we review the corneal imaging methods for the diagnosis of preclinical KC.
methodAn online literature search was carried out on PubMed. Only publications detailing corneal assessment procedures were considered for this review and any publication on instruments that did not generate KC predictability indices were also excluded from the review. The 308 publications were reviewed. DISCUSSION: Corneal assessment techniques, with the ability to characterise both the anterior and posterior corneal surfaces, are invaluable in the diagnosis of pre-clinical KC. Reflection based and elevation based corneal imaging systems should be used in conjunction with other assessments such as higher order aberration measuring systems to improve sensitivity and reliability in the diagnosis of pre-clinical KC. Ultra high resolution ultrasound can detect pre-clinical KC. The ability to asses both the epithelium and endothelium makes anterior surface optical coherence tomography a superior technique for pre-clinical KC diagnosis. There is a positive correlation between central corneal thickness and corneal hysteresis. Corneal biomechanics should be considered in conjunction with other corneal assessments in the diagnosis of pre-clinical KC.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.