Evidence map›Paper›PMID 31916939›Full record

ArticleeLife2020

Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex.

Viktor Szegedi, Melinda Paizs, Judith Baka, Pál Barzó, Gábor Molnár, Gabor Tamas, Karri Lamsa

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 47 citations in OpenAlex.

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  10. Parvalbumin interneuron deficits in schizophrenia.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Viktor Szegedi *MTA-NAP Research Group for Inhibitory Interneurons and Plasticity, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.ORCID https://orcid.org/0000-0003-4191-379X
Melinda Paizs *MTA-NAP Research Group for Inhibitory Interneurons and Plasticity, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
Judith BakaMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
Pál BarzóDepartment of Neurosurgery, University of Szeged, Szeged, Hungary.
Gábor MolnárMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
Gabor TamasMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.ORCID http://orcid.org/0000-0002-7905-6001
Karri LamsaMTA-NAP Research Group for Inhibitory Interneurons and Plasticity, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.ORCID https://orcid.org/0000-0002-4609-1337
University of Szeged · HU

Funding

ERC INTERIMPACTMinistry of Human Capacities 20391-3/2018/FEKUSTRATMinistry of Human Capacities Hungary 20391-3/2018/FEKUSTRATNational Research Development and Innovation Office GINOP-2.3.2-15-2016-00018National Research Development and Innovation Office National Brain Research ProgrammeNational Research Development and Innovation Office OTKA K128863National Research, Development and Innovation Office OTKA K128863National Research, Development and Innovation Office of Hungary GINOP-2.3.2-15-2016-00018NKFIH National Brain Research ProgrammeUniversity of Szeged Open Access Fund 4373University of Szeged Open Access Fund 4373
6 · The paper itself

Abstract

Inhibitory autapses are self-innervating synaptic connections in GABAergic interneurons in the brain. Autapses in neocortical layers have not been systematically investigated, and their function in different mammalian species and specific interneuron types is poorly known. We investigated GABAergic parvalbumin-expressing basket cells (pvBCs) in layer 2/3 (L2/3) in human neocortical tissue resected in deep-brain surgery, and in mice as control. Most pvBCs showed robust GABA

Indexed as

AnimalsAxonsBrainCarisoprodolDendritesElectrophysiologyFemaleGABA AgentsHumansInterneuronsMaleMiceMicroscopy, ElectronNeocortexParvalbuminsPatch-Clamp TechniquesCarisoprodolGABA AgentsParvalbuminsbasket cellselectron microscopyelectrophysiologyhumanimmunocytochemistryinhibitionmouseneurosciencepatch-clamp methodology

Identifiers

PMID31916939
PMCPMC6984819
OpenAlexW3000700826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.