ArticleMonoclonal antibodies in immunodiagnosis and immunotherapy2020
Generation of Rat Monoclonal Antibodies Specific for Human Stromal Cell-Derived Factor-2.
Article in Monoclonal antibodies in immunodiagnosis and immunotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- Monoclonal Antibody Against Stromal Cell-Derived Factor 2.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2020Article
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7 authors at 2 institutions in 1 country.
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Abstract
Stromal cell-derived factor-2 (SDF-2) is reportedly involved in multiple endoplasmic reticulum (ER) functions, including the misfolded protein catabolic process, protein glycosylation, and ER protein quality control. However, the precise molecular and cellular functions of SDF-2 remain unknown. Previously, we discovered that SDF-2 mediates acquired resistance to oxaliplatin in human gastric cancer cells. In this study, we have generated SDF-2-specific monoclonal antibodies (mAbs), using the rat medial iliac lymph node method, as a tool to explore novel mechanisms of oxaliplatin resistance. The antibodies detected endogenous human SDF-2 in immunoblotting analyses. In addition, immunoprecipitation analyses revealed the availability of these antibodies for human SDF-2. Thus, these mAbs will be available to elucidate molecular and cellular functions of SDF-2 in cancer cells.
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